75392-65-3

Basic information

• Product Name: 4-((E)-4-((E)-styryl)styryl)pyridine
• Synonyms: 4-((E)-4-((E)-styryl)styryl)pyridine
• CAS NO: 75392-65-3
• Molecular Weight: 283.373
• Mol File: 75392-65-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-((E)-4-((E)-styryl)styryl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((E)-4-((E)-styryl)styryl)pyridine(75392-65-3)
• EPA Substance Registry System: 4-((E)-4-((E)-styryl)styryl)pyridine(75392-65-3)

Safety Data

• Hazardous Substances Data: 75392-65-3(Hazardous Substances Data)

Upstream product

• 1449-46-3 benzyltriphenylphosphonium bromide 
• 118528-62-4 4-<2-(4-pyridyl)ethenyl>benzaldehyde 
• 100-39-0 benzyl bromide 
• 108-88-3 toluene 
• 623-27-8 terephthalaldehyde, 
• 108-89-4 picoline 
• 100-43-6 4-vinylpyridine 
• 51044-13-4 4-bromobenzyl triphenylphosphonium bromide 
• 100-52-7 benzaldehyde 
• 718-24-1 (E)-4-(4-methylstyryl)pyridine 
• 780-21-2 N-(4-chlorobenzylidene)aniline 

Downstream Products

• 1416252-35-1 C₂₁H₁₇NO 

Relevant articles and documents

Anti-oligomerization sheet molecules: Design, synthesis and evaluation of inhibitory activities against α-synuclein aggregation

Aggregation of α-synuclein (α-Syn) play a key role in the development of Parkinson Disease (PD). One of the effective approaches is to stabilize the native, monomeric protein with suitable molecule ligands. We have designed and synthesized a series of sheet-like conjugated compounds which possess different skeletons and various heteroatoms in the two blocks located at both ends of linker, which have good π-electron delocalization and high ability of hydrogen-bond formation. They have shown anti-aggregation activities in vitro towards α-Syn with IC50 down to 1.09 μM. The molecule is found binding in parallel to the NACore within NAC domain of α-Syn, interfering aggregation of NAC region within different α-Syn monomer, and further inhibiting or slowing down the formation of α-Syn oligomer nuclei at lag phase. The potential inhibitor obtained by our strategy is considered to be highly efficient to inhibit α-Syn aggregation.

Anil-Synthese. 22 Mitteilung. Ueber die Herstellung von Styryl und Distyryl-Derivaten des Pyridins

2,4-, 2,5- and 2,6-Dimethylpyridines react with anils of aromatic aldehydes in the presence of dimethylformamide and potassium hydroxide to yield the corresponding distyrylpyridines ('anil synthesis').Under the same reaction conditions (4-methylstyryl)pyridines are converted to (stilbenylvinyl)pyridines.Similarly, the Schiff's base derived from pyridine-3-carbaldehyde and chloranile on treatment with methyl- and p-tolyl-substituted aromatic hetericycles gives the corresponding (heteroaryl-styryl)pyridines, whereas with the Schiff's bases derived from pyridine-2= and -4-carbaldehyde side reactions, such as dimerization followed by disproportionation predominate.