754159-15-4

Basic information

• Product Name: 2-(1-Methyl-1H-pyrazol-4-yl)acetonitrile
• Synonyms: 2-(1-Methyl-1H-pyrazol-4-yl)acetonitrile;2-(1-Methyl-1H-pyrazol-4-...
• CAS NO: 754159-15-4
• Molecular Formula: C6H7N3
• Molecular Weight: 121.13988
• Mol File: 754159-15-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(1-Methyl-1H-pyrazol-4-yl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-Methyl-1H-pyrazol-4-yl)acetonitrile(754159-15-4)
• EPA Substance Registry System: 2-(1-Methyl-1H-pyrazol-4-yl)acetonitrile(754159-15-4)

Safety Data

• RIDADR: UN2810
• Hazardous Substances Data: 754159-15-4(Hazardous Substances Data)

Usage

General Description

2-(1-Methyl-1H-pyrazol-4-yl)acetonitrile is a chemical compound with the molecular formula C8H8N4. It is a derivative of pyrazole and is used in the synthesis of various pharmaceuticals and agrochemicals. 2-(1-Methyl-1H-pyrazol-4-yl)acetonitrile is also known for its potential as an intermediate in the production of other organic compounds. It is important to handle this chemical with caution and follow proper safety protocols, as it can pose health hazards if not handled properly.

Upstream product

• 25016-11-9 1-methylpyrazole-4-carbaldehyde 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 735241-98-2 4-(chloromethyl)-1-methyl-1H-pyrazole 
• 154312-86-4 4-(chloromethyl)-1-methyl-1H-pyrazole hydrochloride 
• 13435-20-6 tetraethylammoniumcyanide 
• 5697-44-9 p-tolylsulfonylmethyl isocyanide 

Downstream Products

• 891494-63-6 MK-8776 
• 1152582-56-3 2-(1-methyl-1H-pyrazol-4-yl)acetic acid 

Relevant articles and documents

A convergent preparation of the CHK1 inhibitor MK-8776 (SCH 900776)

This Letter describes the development of a convergent, efficient route to the CHK1 inhibitor MK-8776. This synthetic approach relies upon the cyclization of a bispyrazole adduct 10 with a optically pure β-keto nitrile 9 to construct the pyrazolo[1,5-a]pyrimidine scaffold in a single step.

COMPOSITIONS AND METHODS FOR TREATING CANCER

The instant invention provides a method of treating a cancer, selected from the group consisting of breast cancer, melanoma, colorectal cancer, non-small cell lung cancer and ovarian cancer, by administering a combination of a WEE1 inhibitor and a CHK1 inhibitor, wherein the WEE1 inhibitor is MK-1775 or a pharmaceutically acceptable salt thereof, or MK-3652 or a pharmaceutically acceptable salt thereof, and the CHK1 inhibitor is MK-8776 or a pharmaceutically acceptable salt thereof, or SCH900444 or a pharmaceutically acceptable salt thereof.

SYNTHESIS OF SUBSTITUTED-3-AMINOPYRAZOLES

The present invention discloses a process of preparing compound of formula (I): wherein A, M, and Z are as defined herein. An example of a compound of formula (I) is 3-amino-1-methyl-1H-1'H-4,4'-bispyrazole.