75418-74-5

Basic information

• Product Name: 3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTER
• Synonyms: methyl 3-oxo-3-(pyridin-2-yl)propanoate;Methyl 3-oxo-3-(pyridin-2-yl);3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTER
• CAS NO: 75418-74-5
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.174
• Mol File: 75418-74-5.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTER(75418-74-5)
• EPA Substance Registry System: 3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTER(75418-74-5)

Safety Data

• Hazardous Substances Data: 75418-74-5(Hazardous Substances Data)

Usage

General Description

3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTER is a chemical compound with the molecular formula C10H11NO3. It is a methyl ester derivative of 3-oxo-3-pyridin-2-ylpropionic acid, and it is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceutical intermediates. 3-OXO-3-PYRIDIN-2-YLPROPIONIC ACID METHYL ESTER has a pyridine ring with a propionic acid side chain and a ketone group, making it a valuable molecule for drug discovery and development. Its chemical structure and properties make it suitable for various applications in medicinal chemistry and pharmaceutical research.

Upstream product

• 67-56-1 methanol 
• 78570-34-0 3,3-bis(methylsulfanyl)-1-pyridin-2-ylprop-2-en-1-one 
• 2459-07-6 methyl pyridine-2-carboxylate 
• 79-20-9 acetic acid methyl ester 
• 75399-09-6 (Z)-3-Hydroxy-3-pyridin-2-yl-acrylic acid methyl ester 
• 1122-62-9 2-acetylpyridine 
• 616-38-6 carbonic acid dimethyl ester 
• 38330-80-2 monomethyl monopotassium malonate 
• 100312-28-5 imidazol-1-yl-pyridin-2-yl-methanone 
• 98-98-6 2-Picolinic acid 
• 107-31-3 Methyl formate 

Downstream Products

• 954230-71-8 5-pyridin-2-ylisoxazole-4-carboxylic acid 
• 1122-62-9 2-acetylpyridine 
• 108309-67-7 3-p-methoxybenzylthio-3-(2-pyridyl)propanol 
• 153869-33-1 methyl 3-benzoylthio-3-(2-pyridyl)propionate 
• 153869-34-2 methyl 3-p-methoxybenzylthio-3-(2-pyridyl)propionate 
• 1268849-81-5 2-(3-(benzyloxy)phenyl)-6-(pyridin-2-yl)pyrimidin-4-ol 
• 1361236-11-4 1-methyl-2-phenyl-5-(pyridin-2-yl)-1H-pyrazol-3(2H)-one 
• 1361236-29-4 1-methyl-3-oxo-2-phenyl-5-(pyridin-2-yl)-2,3-dihydro-1H-pyrazole-4-carboxylic acid 
• 1361236-21-6 1-methyl-3-oxo-2-phenyl-5-(pyridin-2-yl)-2,3-dihydro-1H-pyrazole-4-carbaldehyde 
• 21683-60-3 2-phenyl-5-pyridin-2-yl-1,2-dihydro-pyrazol-3-one 
• 1597403-95-6 N-(3,4-dimethoxybenzyl)-5-(3,5-dimethylphenyl)-[2,2'-bipyridine]-3-carboxamide 

Relevant articles and documents

Compound with BRD4 inhibitory activity, preparation method and application thereof

The invention discloses a compound with BRD4 inhibitory activity, a preparation method and application thereof. The structure of the compound with the BRD4 inhibitory activity is shown as a formula I, and definitions of substituent groups are shown in the specification and claims. The compound provided by the invention has very high bromodomain protein inhibition activity, especially BRD4 targeted inhibition activity, and can be used for treating or/and preventing related diseases mediated by bromodomain protein.

HETEROCYCLIC COMPOUND

A compound represented by the formula (I): wherein each symbol is as described in the SPECIFICATION, or a salt thereof has a PDE2A inhibitory action, and is useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like.

Rhodium Catalyzed Asymmetric Hydrogenation of 2-Pyridine Ketones

Catalyzed by [Rh(COD)Binapine]BF4, the asymmetric hydrogenation of 2-pyridine ketones has been achieved with excellent enantioselectivities (enantiomeric excesses up to 99%) under mild conditions. This method is suitable for various kinds of 2-pyridine ketones and their derivatives. A number of enantiomerically pure chiral 2-pyridine-aryl/alkyl alcohols were prepared through hydrogenation, which can be used directly in organic synthesis.