75470-78-9Relevant articles and documents
Small molecule compound bonded with alpha-synuclein aggregate, and preparation method and application thereof
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Paragraph 0024-0025; 0029; 0048, (2021/04/14)
The invention belongs to the technical field of medicine, and relates to a compound capable of being bonded with alpha-synuclein aggregate, and a preparation method and application thereof. The structural general formula of the compound is shown in the formula I, wherein m is a positive integer selected from 1 to 3, R1 is respectively selected from phenyl, substituted phenyl, naphthyl, biphenyl, 5-6-membered aromatic heterocycle and substituted 5-6-membered aromatic heterocycle, and R2 is selected from benzyl, C1-3 alkyl naphthyl, C1-3 alkyl, phenyl, substituted phenyl, 5-6-membered heteroaromatic ring and substituted 5-6-membered heteroaromatic ring. The compound disclosed by the invention can be strongly bonded with alpha-synuclein aggregate, can be used as an imaging tracer agent required by image examination technologies such as PET (Polyethylene Terephthalate) and SPECT (Single Photon Emission Computed Tomography) for clinical disease diagnosis or used for preparing the imaging tracer agent and preparing a composition comprising the imaging tracer agent, and used for detecting diseases related to alpha-synuclein misfolding and abnormal aggregation, such as Parkinson's disease, and has a remarkable good application prospect.
Radical Ions of 3-Styryl-quinoxalin-2-one Derivatives Studied by Pulse Radiolysis in Organic Solvents
Skotnicki, Konrad,De La Fuente, Julio R.,Ca?ete, álvaro,Berrios, Eduardo,Bobrowski, Krzysztof
, p. 4051 - 4066 (2018/04/20)
The absorption-spectral and kinetic behaviors of radical ions and neutral hydrogenated radicals of seven 3-styryl-quinoxalin-2(1H)-one (3-SQ) derivatives, one without substituents in the styryl moiety, four others with electron-donating (R = -CH3/su
Experimental and theoretical studies for mild steel corrosion inhibition in 1.0 M HCl by three new quinoxalinone derivatives
Tazouti,Galai,Touir,Touhami, M. Ebn,Zarrouk,Ramli,Sara?o?lu,Kaya,Kandemirli,Kaya
, p. 815 - 832 (2016/07/06)
Three quinoxalinone derivatives, namely (E)-3-styrylquinoxalin-2(1H)-one (SQ), (E)-3-(4-methoxystyryl)quinoxalin-2(1H)-one (MOSQ) and (E)-3-(4-methoxystyryl)-7-methylquinoxalin-2(1H)-one (MOSMQ) were synthesized and characterized. Thus, their inhibition e