75504-01-7Relevant articles and documents
Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy
Buchman, Cameron D.,Buckanovich, Ronald J.,Chtcherbinine, Mikhail,Debnath, Bikash,Felton, Jeremy,Grimley, Edward,Huddle, Brandt C.,Hurley, Thomas D.,Larsen, Scott D.,Li, Siwei,Mao, Shuai,McGonigal, Stacy C.,Neamati, Nouri,Pan, Shu,Sun, Duxin,Takahashi, Cyrus,Wen, Bo
, (2020/12/21)
There is strong evidence that inhibition of one or more Aldehyde Dehydrogenase 1A (ALDH1A) isoforms may be beneficial in chemotherapy-resistant ovarian cancer and other tumor types. While many previous efforts have focused on development of ALDH1A1 select
SMALL MOLECULE INHIBITORS OF ALDH AND USES THEREOF
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Page/Page column 101, (2018/04/12)
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a thiopyrimidinone structure which function as inhibitors of ALDH protein, and their use as therapeutics for the treatment of cancer and other diseases.
N-alkylation of lactams with secondary heterobenzylic bromides
Yu, Ming,Stevenson, Karis,Zhou, Gene
, p. 5591 - 5594 (2014/12/11)
We herein report a general N-alkylation reaction of lactams with secondary heterobenzylic bromides. This methodology features mild reaction condition, moderate to high product isolation yield, and broad substrate scope. Good chemical and structural tolerance has also been demonstrated by both the secondary heterobenzylic bromides and lactam substrates.