75530-94-8 Usage
Description
4-(3-Nitrophenyl)-2-dimethoxymethyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 5-Isopropyl Ester 3-Methyl Ester (CAS# 75530-94-8) is a complex organic compound characterized by its yellow liquid appearance. It is primarily utilized in the field of organic synthesis, where its unique chemical structure contributes to the creation of various other compounds.
Uses
Used in Organic Synthesis:
4-(3-Nitrophenyl)-2-dimethoxymethyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 5-Isopropyl Ester 3-Methyl Ester is used as a synthetic intermediate for the development of other organic compounds. Its chemical properties and structure make it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-(3-Nitrophenyl)-2-dimethoxymethyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 5-Isopropyl Ester 3-Methyl Ester is used as a key component in the synthesis of novel drug candidates. Its unique structure allows for the development of new molecules with potential therapeutic applications, contributing to the advancement of medical treatments.
Used in Agrochemical Industry:
4-(3-Nitrophenyl)-2-dimethoxymethyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 5-Isopropyl Ester 3-Methyl Ester is also employed in the agrochemical industry for the synthesis of new compounds with potential applications in crop protection and pest control. Its incorporation into the development process can lead to the creation of innovative products that enhance agricultural productivity and sustainability.
Used in Specialty Chemicals:
In the specialty chemicals sector, 4-(3-Nitrophenyl)-2-dimethoxymethyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 5-Isopropyl Ester 3-Methyl Ester is utilized for the synthesis of compounds with specific applications in various industries, such as materials science, coatings, and adhesives. Its unique properties enable the development of tailored solutions for specific industrial needs.
Check Digit Verification of cas no
The CAS Registry Mumber 75530-94-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,5,3 and 0 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 75530-94:
(7*7)+(6*5)+(5*5)+(4*3)+(3*0)+(2*9)+(1*4)=138
138 % 10 = 8
So 75530-94-8 is a valid CAS Registry Number.
75530-94-8Relevant articles and documents
Conformationally constrained 1,4-DHPs. A convenient route to bis-1,4-DHPs as a novel class of nitrogen compounds
Marchalín, ?tefan,Chudík, Miloslav,Cvopová, Katarína,Kozí?ek, Jozef,Le?ko, Ján,Da?ch, Adam
, p. 5747 - 5754 (2007/10/03)
2-Formyl-1,4-DHP derivatives 2 undergo the tandem Knoevenagel condensation/amino-nitrile cyclisation with activated methylene reagents to afford high functionalised indolizines. However, in the absence of this tandem, the Knoevenagel condensation intermediate leads to bis-1,4-DHPs as a new class of nitrogen compounds.
Studies on nilvadipine. I. Synthesis and structure-activity relationships of 1,4-dihydropyridines containing novel substituents at the 2-position
Satoh,Ichihashi,Okumura
, p. 3189 - 3201 (2007/10/02)
The synthesis of new 1,4-dihydropyridine derivatives containing novel substituent at the 2-position of the nucleus via the key intermediate 2-formyl-1,4-dihydropyridines (X), is described. The aldehydes (X) were prepared by hydrolysis of the acetals (IX) which were obtained from aryl aldehyde (V) and alkyl 4,4-dialkoxyacetoacetate (VI) by the Knoevenagel reaction and treatment with alkyl 3-aminocrotonate (VIII) according to the modified Hantzsch method. The formyl group of the aldehydes (X) was reactive enough to be converted to a variety of functional groups such as hydroxymethyl, cyano, substituted iminomethyl, carbamoyl, semicarbazone, substituted vinyl, ethynyl, and so on. In all of the novel compounds we prepared, 2-hydroxymethyl- and 2-cyano-1,4-dihydropyridines (IV and XXII) were found to possess potent activities in preliminary biological evaluations on hypotension in normotensive rats and on an increase in coronary blood flow in pentobarbital-anesthetized dogs. Optimization research in order to obtain a more potent compound was accomplished in the 2-hydroxymethyl- and 2-cyano-1,4-dihydropyridine series. We selected isopropyl 2-cyano-3-methoxycarbonyl-4-(3-nitrophenyl)-6-methyl-1,4-dihydropyridin e-5-carboxylate (XXIIj) as a candidate compound for further biological evaluation studies. Fortunately, XXIIj (nilvadipine) has been accepted in clinical use for the treatment of hypertension.