75558-06-4

Basic information

• Product Name: C₁₀H₈O₄S
• Synonyms: C₁₀H₈O₄S
• CAS NO: 75558-06-4
• Molecular Weight: 224.237
• Mol File: 75558-06-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: C₁₀H₈O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₈O₄S(75558-06-4)
• EPA Substance Registry System: C₁₀H₈O₄S(75558-06-4)

Safety Data

• Hazardous Substances Data: 75558-06-4(Hazardous Substances Data)

Upstream product

• 110-00-9 furan 
• 75532-25-1 2,2,4,4-tetrahydrothiophene-3,4-dicarboxylic acid anhydride 

Relevant articles and documents

SYNTHESIS OF CANTHARIDIN

The invention provides synthetic methods for the preparation of cantharidin and analogs thereof. In one aspect, the invention provides an improved Diels-Alder cycloaddition to generate a key intermediate en route to cantharidin and analogs thereof. In certain embodiments, the new Diels-Alder reaction involves reacting Compound (2) in the presence of furan, and in the absence of acid or increased pressure, in an aprotic polar solvent with slight warming, to yield Compound (1) in favorable yield and exo-endo ratio. In another aspect, the invention also provides a new Diels-Alder reaction between compounds of Formula (III) and furan to yield compounds of Formula (IV), which can then be transformed into cantharidin or analogs thereof. In yet another aspect, the invention describes a new palladium-mediated carbonylation providing another key intermediate en route to cantharidin and analogs thereof. In addition to synthetic methods, present invention also provides compounds {i.e., intermediates) useful in the synthesis of cantharidin and analogs thereof. Compounds provided herein may have biological activity, and therefore may be used in the treatment of diseases or conditions {e.g., infectious diseases and skin conditions).

Compositions and methods for the protection of nucleophilic groups

The present invention provides compositions, methods, and kits relating to the protection and deprotection of molecules comprising nucleophilic groups, such as the protection and deprotection of thermostable polymerases. Also provided are methods of performing nucleic acid amplification using polymerases protected according to the invention.

Organic Reactions at High Pressure. The Preparative Scale Synthesis of Cantharidin

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