75567-58-7 Usage
Description
3-Nitro-1-Methyl-5H-pyrido[4,3-b]indole is a chemical compound belonging to the indole family, characterized by its nitro and methyl functional groups. It is a derivative of tryptophan, an essential amino acid, and is known for its mutagenic and carcinogenic properties.
Uses
Used in Research Applications:
3-Nitro-1-Methyl-5H-pyrido[4,3-b]indole is used as a mutagen and carcinogen in research for studying the effects of such compounds on biological systems, particularly in the context of genetic mutations and cancer development. It serves as a model compound for understanding the mechanisms of mutagenicity and carcinogenicity.
Used in Toxicology Studies:
In the field of toxicology, 3-Nitro-1-Methyl-5H-pyrido[4,3-b]indole is used as a test compound to evaluate the mutagenic and carcinogenic potential of various substances. It is particularly used in the Ames test, which employs Salmonella typhimurium TA 98 as a bacterial strain to assess the mutagenicity of chemicals.
Used in Pharmaceutical Development:
Although 3-Nitro-1-Methyl-5H-pyrido[4,3-b]indole itself is mutagenic and carcinogenic, understanding its properties and mechanisms of action can aid in the development of pharmaceuticals that target similar pathways or interact with the same molecular targets, but with reduced or no mutagenic and carcinogenic effects.
Used in Environmental Monitoring:
3-Nitro-1-Methyl-5H-pyrido[4,3-b]indole can be used as a reference compound in environmental monitoring to detect and quantify the presence of mutagenic and carcinogenic substances in the environment, which can pose risks to human health and the ecosystem.
Check Digit Verification of cas no
The CAS Registry Mumber 75567-58-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,5,6 and 7 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 75567-58:
(7*7)+(6*5)+(5*5)+(4*6)+(3*7)+(2*5)+(1*8)=167
167 % 10 = 7
So 75567-58-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H9N3O2/c1-7-12-8-4-2-3-5-9(8)14-10(12)6-11(13-7)15(16)17/h2-6,14H,1H3
75567-58-7Relevant articles and documents
Synthesis and characterization of the aqueous solution chemistry of the food-derived carcinogen model N-acetoxy-N-(1-methyl-5H-pyrido[4,5-b]indol-3-yl)acetamide and its N-pivaloyloxy analogue
Rajagopal, Sridharan,Brooks, Michael E.,Nguyen, Thach-Mien,Novak, Michael
, p. 8003 - 8010 (2007/10/03)
We report the synthesis of N-acetoxy-N-(1-methyl-5H-pyrido[4,5-b]indol-3-yl)acetamide, 7, its N-pivaloyloxy analogue, 9, and improved synthesis of indole-2-acetonitrile, 3 (70% in five steps from indole-2-carboxylic acid), the carcinogenic amine Trp-P-2, 4 (40% from 3), and the nitro compound, 5 (40% from 4 by oxidation with H2O2 using Mo(CO)6 catalyst). In aqueous solution at neutral pH, 7 primarily undergoes C-O bond cleavage to yield the hydroxamic acid, 8, but under the same conditions the sterically hindered 9 decomposes predominately by N-O bond cleavage with a pH independent rate constant that is 7.5-fold smaller than that for 7. In the pH range 0.5-7.0 three different processes for the decomposition of 9 were detected by kinetics. Only the process that dominates at neutral pH generates a nitrenium species that can be trapped by N3-.
