75586-27-5

Basic information

• Product Name: isoquinoline N-p-benzenesulphonylimine
• Synonyms: isoquinoline N-p-benzenesulphonylimine
• CAS NO: 75586-27-5
• Molecular Weight: 284.338
• Mol File: 75586-27-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: isoquinoline N-p-benzenesulphonylimine(CAS DataBase Reference)
• NIST Chemistry Reference: isoquinoline N-p-benzenesulphonylimine(75586-27-5)
• EPA Substance Registry System: isoquinoline N-p-benzenesulphonylimine(75586-27-5)

Safety Data

• Hazardous Substances Data: 75586-27-5(Hazardous Substances Data)

Upstream product

• 119-65-3 isoquinoline 
• 98-59-9 p-toluenesulfonyl chloride 
• 80-17-1 benzenesufonyl hydrazide 
• 38846-64-9 2-ethynylbenzaldehyde 
• 25705-34-4 2-(2-oxoethyl)benzaldehyde 

Relevant articles and documents

Synthesis of pyrido[1,2-b]indazoles via aryne [3+2] cycloaddition with N-tosylpyridinium imides

The [3 + 2] cycloaddition of arynes with N-tosylpyridinium imides, followed by an elimination of Ts-, affords pyrido[1,2-b]indazoles under mild reaction conditions in good yields.

The Reactions of 2-Alkynylbenzaldehydes with Hydrazides: a Route to Isoquinoline N-Imines

Sulphonyl- and acyl-hydrazones of 2-ethynylbenzaldehyde cyclise in the presence of base to give isoquinoline N-imines in moderate yield.The suggested mechanism involves primapy formation of the hydrazone anion followed by nucleophilic attack on the alkyne bond, either by anionic nitrogen to give an unstable 3H-2,3-benzodiazepine which rearranges to the isoquinoline N-imine, or by the neutral imine nitrogen to give the isoquinoline system directly.Attempts to extend the reaction to the semicarbazone and 2,4-dinitrophenylhydrazone were not successful.