7559-49-1

Basic information

• Product Name: Methanesulfonothioic acid, S-(4-methylphenyl) ester
• CAS NO: 7559-49-1
• Molecular Formula: C8H10O2S2
• Molecular Weight: 202.298
• Mol File: 7559-49-1.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Methanesulfonothioic acid, S-(4-methylphenyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonothioic acid, S-(4-methylphenyl) ester(7559-49-1)
• EPA Substance Registry System: Methanesulfonothioic acid, S-(4-methylphenyl) ester(7559-49-1)

Safety Data

• Hazardous Substances Data: 7559-49-1(Hazardous Substances Data)

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 10439-23-3 4-methylbenzenesulfinyl chloride 
• 6873-87-6 N-butyl-4-methylbenzene-1-sulfinamide 
• 20277-69-4 sodium methansulfinate 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 10409-07-1 bis(4-methylphenyl)disulfone 
• 67-68-5 dimethyl sulfoxide 
• 106-45-6 para-thiocresol 
• 103-19-5 di(p-tolyl) disulfide 
• 39549-10-5 1-[(4-methylphenyl)sulfanyl]pyrrolidine-2,5-dione 
• 24398-14-9 1-[(diethylamino)sulfanyl]-4-methylbenzol 
• 118063-38-0 Methanethiosulfonic acid S-(2,4-dinitro-phenyl) ester 
• 933-00-6 p-methylbenzenesulfenyl chloride 

Downstream Products

• 131947-30-3 2-phenyl-3-(4-tolylthio)imidazo<1,2-a>pyridine 

Relevant articles and documents

Direct conversion of sulfinamides to thiosulfonates without the use of additional redox agents under metal-free conditions

Direct conversion of sulfinamides to thiosulfonates is described. Without the use of additional redox agents, the reaction proceeds smoothly in the presence of TFA under metal-free conditions. This protocol possesses many advantages such as odourless and stable starting materials, broad substrate scope, selective synthesis, and mild reaction conditions. This journal is

Atom transfer radical addition to styrenes with thiosulfonates enabled by synergetic copper/photoredox catalysis

A synergetic copper/photoredox catalyzed ATRA of styrenes and thiosulfonates is developed. Besides aryl ethylenes, the challenging α-substituted styrenes were employed to construct the benzylic quaternary carbon centers. Owing to the mild conditions as well as the high level of substrate compability, this ATRA could be applied to derivatize bioactive natural products in late stage, and to install fluorophores across alkenes. The mechanistic studies reveal sulfonyl radicals as the key intermediate in the transformation.

Synthetic method for preparing thiosulfonates on basis of sulfinic acid sodium salt disproportionated reaction

The invention relates to a synthetic method for preparing thiosulfonates on the basis of a sulfinic acid sodium salt disproportionated reaction. The preparation method comprises the steps that sulfinic acid sodium salts serve as the raw materials, boron trifluoride diethyl etherate serves as accelerant, dichloromethane serves as solvent, and by means of a disproportionation coupled reaction, a thiosulfinate compound with good biological activity is synthesized; two different sulfinic acid sodium salts serve as the raw materials, and by means of a crossed disproportionation coupled reaction method, an asymmetric thiosulfinate compound can be synthesized. By means of a one-pot method and a two-step method, and by means of a thiosulfonates intermediate prepared on site, a sulfones compound and a sulfonamides compound can be synthesized by directly starting from sulfinic acid sodium salts. Accordingly, a synthetic route for preparing thiosulfonates on the basis of the sulfinic acid sodiumsalt disproportionated reaction is provided for the first time, operation is easy, raw materials are easy to obtain, the condition is mild, no metal catalyst is needed, no additional oxidant or reductant is needed, and the prepared thiosulfonates can have the good biological activity, and can also serve as the intermediate of the reaction to be applied to organic synthesis.