75599-23-4

Basic information

• Product Name: cis-N,N'-DiMethyl-1,2-diaMinocyclohexane
• Synonyms: cis-N,N'-DiMethyl-1,2-diaMinocyclohexane;(1R,2S)-rel-N1,N2-Dimethyl-1,2-cyclohexanediamine;cis-N,N'-Dimethyl-1,2-diaminocy;cis-N,N-Dimethyl-1,2-cyclohexanediamine
• CAS NO: 75599-23-4
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142.24192
• Mol File: 75599-23-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 186.8±8.0 °C(Predicted)
• Appearance: /
• Density: 0.89±0.1 g/cm3(Predicted)
• PKA: 11.04±0.40(Predicted)
• CAS DataBase Reference: cis-N,N'-DiMethyl-1,2-diaMinocyclohexane(CAS DataBase Reference)
• NIST Chemistry Reference: cis-N,N'-DiMethyl-1,2-diaMinocyclohexane(75599-23-4)
• EPA Substance Registry System: cis-N,N'-DiMethyl-1,2-diaMinocyclohexane(75599-23-4)

Safety Data

• Hazardous Substances Data: 75599-23-4(Hazardous Substances Data)

Usage

Description

cis-N,N'-DiMethyl-1,2-diaMinocyclohexane, also known as cis-1,2-dimethyl-1,2-diaminocyclohexane, is an organic compound with a cyclohexane ring and two methyl groups attached to the nitrogen atoms in a cis configuration. It is a versatile chemical intermediate and catalyst used in various chemical reactions and synthesis processes.

Uses

Used in Pharmaceutical Industry:
cis-N,N'-DiMethyl-1,2-diaMinocyclohexane is used as a reactant for the synthesis of fluorinated 4-aminopyridine derivatives, which are important building blocks in the development of pharmaceutical compounds with potential therapeutic applications.
Used in Chemical Research:
cis-N,N'-DiMethyl-1,2-diaMinocyclohexane is used as a catalyst in the synthesis of blebbiastatin, a chemical tool used in biological research. Blebbiastatin is a small molecule that inhibits actin polymerization and is used to study the role of actin dynamics in cellular processes.

Upstream product

• 942606-10-2 (S,S)-1,2-diaminocyclohexane-N,N'-diethyl carbamate 
• 122743-11-7 N-((1S,2S)-2-Formylamino-cyclohexyl)-formamide 
• 21436-03-3 (S,S)-1,2-diaminocyclohexane 
• 51066-08-1 7-methyl-7-azabicyclo[4.1.0]heptane 
• 286-20-4 cyclohexane-1,2-epoxide 
• 20431-81-6 rac-trans-2-methylamino-cyclohexanol 
• 61798-24-1 trans-N,N'-dimethylcyclohexane-1,2-diamine 
• 74-89-5 methylamine 
• 1121-22-8 trans-1,2-Diaminocyclohexane 
• 77069-67-1 cis-N,N'-Diformyl-1,2-cyclohexandiamin 
• 1436-59-5 cis-cyclohexane-1,2-diamine 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 132076-19-8 (3aS,7aS)-2<(1R)-methyl-2-phenylethyl>-<3a,4,5,6,7,7a-octahydro-1,3-dimethyl-1,3,2-benzodiazaphosphole>-2-oxide 
• 132076-20-1 (3aS,7aS)-2<(1S)-methyl-2-phenylethyl>-<3a,4,5,6,7,7a-octahydro-1,3-dimethyl-1,3,2-benzodiazaphosphole>-2-oxide 
• 473918-48-8 N-(2-aminophenyl)indole 
• 3419-91-8 N-(2-pyridyl)indole 
• 16096-33-6 1-phenyl-1H-indole 
• 174621-50-2 1-(4-ethoxycarbonylphenyl)indole 
• 883-39-6 1-phenyl-1H-benzotriazole 

Relevant articles and documents

Method for synthesizing trans-cyclohexanedimethanamine

The invention discloses a method for synthesizing trans-cyclohexanedimethanamine, comprising steps of reacting cyclohexene oxide and methylamine aqueous solution under the catalysis of boric acid, and then adding sulfuric acid, dewatering to form an ester, ring-closing under alkaline conditions, adding methylamine aqueous solution and boric acid for hermetic reaction, and distilling to obtain trans-cyclohexanedimethanamine. The synthetic process is simple to perform, provides facilitated isolation and purification and high yield and product purity, and is suitable for batch production.

NOVEL CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS

This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multipl

The role of chelating diamine ligands in the Goldberg reaction: A kinetic study on the copper-catalyzed amidation of aryl iodides

The mechanistic details of the Cu-catalyzed amidation of aryl iodides are presented. The kinetic data suggest that the diamine ligand prevents multiple ligation of the amide. The formation of an amidocuprate species external to the catalytic cycle helped to rationalize the dependence on diamine concentration and the inverse dependence on amide concentration at low diamine concentrations. The intermediacy of a Cu(I) amidate was established through both its chemical and kinetic competency. Copyright