75618-42-7Relevant articles and documents
Identification of three novel ring expansion metabolites of KAE609, a new spiroindolone agent for the treatment of malaria, in rats, dogs, and humans
Huskey, Su-Er W.,Zhu, Chun-Qi,Lin, Melissa M.,Forseth, Ry R.,Gu, Helen,Simon, Oliver,Eggimann, Fabian K.,Kittelmann, Matthias,Luneau, Alexandre,Vargas, Alexandra,Li, Hongmei,Wang, Lai,Einolf, Heidi J.,Zhang, Jin,Favara, Sarah,He, Handan,Mangold, James B.
, p. 653 - 664 (2016)
KAE609 [(19R,39S)-5,79-dichloro-69-fluoro-39-methyl-29,39,49,99- Tetrahydrospiro[indoline-3,19-pyridol[3,4-b]indol]-2-one] is a potent, fast-acting, schizonticidal agent being developed for the treatment of malaria. After oral dosing of KAE609 to rats and