75715-13-8

Basic information

• Product Name: C₄₂H₄₇N₄O₁₃P
• Synonyms: C₄₂H₄₇N₄O₁₃P
• CAS NO: 75715-13-8
• Molecular Weight: 846.828
• Mol File: 75715-13-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₄₂H₄₇N₄O₁₃P(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₂H₄₇N₄O₁₃P(75715-13-8)
• EPA Substance Registry System: C₄₂H₄₇N₄O₁₃P(75715-13-8)

Safety Data

• Hazardous Substances Data: 75715-13-8(Hazardous Substances Data)

Upstream product

• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 108311-31-5 Methyl-phosphonic acid mono-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester; compound with triethyl-amine 
• 108311-33-7 Carbonic acid (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 114079-04-8 5'-dimethoxytritylthymidine-3'-diisopropylaminomethylphosphonoamidite 
• 252931-78-5 5'-O-DMT thymidylyl 3'-O-acetylthymidine (3',5')-methanephosphonothioate 
• 215862-11-6 C₄₂H₄₅N₂O₉PS 
• 215862-09-2 C₄₂H₄₅N₂O₉PS 
• 185685-72-7 (S_P)-5'-O-dimethoxytritylthymidine 3'-O-methanephosphonoanilidate 
• 21090-30-2 3'-O-acetylthymidine 
• 90865-75-1 (R_P)-5'-O-DMT-thymidylyl-(3',5')-3'-O-acetylthymidine 3'-methanephosphonate 
• 676-83-5 methyldichlorophosphane 
• 83467-48-5 1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 191786-68-2 (R)-Methyl-phosphonic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester 
• 108311-25-7 C₅₃H₆₅N₄O₁₅P 

Relevant articles and documents

Mixed phosphorus-carboxylic anhydrides as synthons for stereoselective synthesis of [RP]-dinucleoside(3',5')-methanephosphonates

The use of 5'-O-DMT-nucleoside 3'-O-(O-2,4,6-trimethylbenzoyl methane-phosphonothioate)s (mixed anhydrides) (3) as intermediates for the preparation of [Rp]-dinucleoside (3',5')-methanephosphonothioates (7) and -methanephosphonates (8) is discussed.

Diastereoselective synthesis of 2'-deoxy and 2'-O-methyl dinucleoside (3',5')-methylphosphonates via alkoxymagnesium chloride-mediated nucleoside coupling

A diastereoselective dinucleoside methylphosphonate synthetic method that features coupling of diastereomerically pure 1,1,1,3,3,3-hexafluoro-2- propyl nucleoside-3'-O-methylphosphonate monomers with 3'-O-protected nucleoside monomers mediated by alkoxymagnesium chloride reagents is described. This synthetic method was found to be diastereospecific in the synthesis of selected 2'-deoxy dinucleoside methyphosphonates and diastereoselective in the synthesis of all sixteen 2'-O-methyl dinucleoside methylphosphonates.