75715-89-8 Usage
Description
Leukotriene E4, also known as LTE4, is a bioactive mediator derived from the metabolism of arachidonic acid through the lipoxygenase pathway. It is chemically related to prostaglandins and thromboxanes and is named leukotrienes due to its origin in leukocytes and its conjugated triene structure. LTE4 plays a significant role in various biological processes, particularly in the immune and inflammatory responses.
Uses
Used in Pharmaceutical Industry:
Leukotriene E4 is used as a therapeutic target for the development of drugs that aim to modulate its activity. This is because LTE4 is involved in the pathophysiology of various inflammatory and allergic diseases, such as asthma, allergic rhinitis, and inflammatory bowel disease. By targeting LTE4, drugs can potentially alleviate symptoms and improve the quality of life for patients suffering from these conditions.
Used in Research and Development:
LTE4 is utilized as a research tool in the study of leukotrienes and their role in immune and inflammatory processes. It helps researchers understand the molecular mechanisms underlying the actions of leukotrienes and identify potential therapeutic targets for the treatment of related diseases.
Used in Diagnostics:
Leukotriene E4 can be used as a biomarker for the assessment of inflammatory and allergic conditions. Measuring the levels of LTE4 in biological samples, such as blood or tissue, can provide valuable information about the severity and progression of these diseases, aiding in the diagnosis and monitoring of patient responses to treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 75715-89-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,7,1 and 5 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 75715-89:
(7*7)+(6*5)+(5*7)+(4*1)+(3*5)+(2*8)+(1*9)=158
158 % 10 = 8
So 75715-89-8 is a valid CAS Registry Number.
InChI:InChI=1/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1
75715-89-8Relevant articles and documents
Total synthesis of leukotrienes from butadiene
Rodriguez, Ana,Nomen, Miguel,Spur, Bernd W.,Godfroid, Jean-Jacques,Lee, Tak H.
, p. 2991 - 3000 (2007/10/03)
The total synthesis of leukotrienes has been achieved starting from butadiene by a palladium-catalyzed telomerization at room temperature. A Sharpless catalytic asymmetric epoxidation generated the asymmetric centers with >94% ee. Simple transformations of the key intermediate 15 produced the leukotrienes LTA4 methyl ester (4), LTC4 (1), LTD4 (2) and LTE4 (3), as well as (14S, 15S)-LTA4 methyl ester (24) and the novel [2H2]-LTA4 methyl ester (28). The use of the opposite chiral director in the Sharpless catalytic asymmetric epoxidation gave the key intermediate 15a that has been used in the synthesis of the double epimers of the leukotrienes as well as LTB4.
SYNTHESIS OF LEUKOTRIENES - NEW SYNTHESIS OF NATURAL LEUKOTRIENE A4
Rokach, Joshua,Young, Robert N.,Kakushima, Masatoshi,Lau, Cheuk-Kun,Seguin, Rick,at al.
, p. 979 - 982 (2007/10/02)
The acetonides of D- or L-glyceraldehyde are chiral synthons for an efficient and versatile synthesis of the natural leukotrienes A4, C4, D4 and E4 and equally can be used to prepare the corresponding unnatural analogues.
