75754-14-2Relevant articles and documents
A method for preparing the amide compounds
-
Paragraph 0036; 0037, (2017/02/09)
The invention discloses a method for preparing an amide compound. The method includes the following specific step: raw materials of a cyano compound and a boric acid compound are heated for a cyan hydrolysis reaction and a carbon-carbon coupling reaction with a mixed solvent of a protic solvent and a non protonic solvent as the reaction medium, in the air atmosphere and in the presence of alkali and a palladium compound catalyst, so as to prepare the amide compound. The novel method for preparing amide compound disclosed by the invention avoids the usage of an oxidant in the prior art, so as to effectively inhibit the excessive hydrolysis of cyano group, avoid further hydrolysis of amide into carboxylic acid, and greatly improve the reaction yield of the amide compound; and the method can be carried out simultaneously with the carbon-carbon coupling reaction to prepare more amide compounds, and has great market value and economic benefit for industrial production of amide compounds.
SYNTHESIS AND STRUCTURE OF MESOMORPHIC 2-CYANO-5--PYRIDINES
Pavlyuchenko, A. I.,Titov, V. V.,Smirnova, N. I.,Grachev, V. T.
, p. 681 - 684 (2007/10/02)
Liquid-crystal 2-cyano-5-pyridines were synthesized by the reaction of 1-dimethylamino-3-dimethylimmonia-2-propene perchlorates with 2-acetylfuran and subsequently through 2-furyl-5-pyrylium perchlorates and 2-(2-furyl)-5-pyridines by conversion of the latter to 5-alkyl(alkoxy)phenylpyridine-2-carboxylic acids, from which the cyano derivatives were obtained by the usual scheme through the amides.The intermediate arylfurylpyridines and arylpyridine-2-carboxylic acid imides also display liquid-crystal properties.
