75782-23-9

Basic information

• Product Name: 1-(2-pyrimidinyl)-3,3-dimethyl-2-butanone
• Synonyms: 1-(2-pyrimidinyl)-3,3-dimethyl-2-butanone
• CAS NO: 75782-23-9
• Molecular Weight: 178.234
• Mol File: 75782-23-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-pyrimidinyl)-3,3-dimethyl-2-butanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-pyrimidinyl)-3,3-dimethyl-2-butanone(75782-23-9)
• EPA Substance Registry System: 1-(2-pyrimidinyl)-3,3-dimethyl-2-butanone(75782-23-9)

Safety Data

• Hazardous Substances Data: 75782-23-9(Hazardous Substances Data)

Upstream product

• 1722-12-9 2-chloropyrimidine 
• 351531-29-8 O-potassio-3,3-dimethyl-2-butanone 
• 75-97-8 3,3-dimethyl-butan-2-one 

Relevant articles and documents

SRN1 Mechanism in Heteroaromatic Nucleophilic Substitution. Reactions Involving Halogenated Pyrimidines, Pyridazines, and Pyrazines

Reactions of 2-chloropyrimidine (1), 4-chloro-2,6-dimethoxypyrimidine (7), 3-chloro-6-methoxypyridazine (9), and 2-chloropyrazine (14) with a representative series of ketone enolates in liquid ammonia exhibited characteristics consistent with a radical-chain (SRN1) mechanism for substituton.Diazines 1 and 9 showed an unexpected sensitivity to enolate ion structure, with 1 reacting best with tertiary enolates and 9 undergoing substitution most satisfactorily with primary enolates.The order of SRN1 reactivity among the various substrates was found to be 14 > 9 > 7 =ca. 1.Thus 1 and 7 required photostimulation at 35o nm for satisfactory displacemement of chloride, 9 underwent some substitution without illumination, and 14 reacted smoothly in the dark.