75784-65-5

Basic information

• Product Name: tert-butyl p-(dimethylamino)benzoate
• Synonyms: tert-butyl p-(dimethylamino)benzoate;4-(Dimethylamino)benzoic acid 1,1-dimethylethyl ester
• CAS NO: 75784-65-5
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.29546
• EINECS: 278-310-2
• Mol File: 75784-65-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 316.5°C at 760 mmHg
• Flash Point: 113°C
• Appearance: /
• Density: 1.029g/cm³
• Vapor Pressure: 0.000408mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: tert-butyl p-(dimethylamino)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl p-(dimethylamino)benzoate(75784-65-5)
• EPA Substance Registry System: tert-butyl p-(dimethylamino)benzoate(75784-65-5)

Safety Data

• Hazardous Substances Data: 75784-65-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H19NO2/c1-13(2,3)16-12(15)10-6-8-11(9-7-10)14(4)5/h6-9H,1-5H3

Upstream product

• 4755-50-4 4-(dimethylamino)benzoyl chloride 
• 75-65-0 tert-butyl alcohol 
• 619-84-1 p-N,N-dimethylaminobenzoic acid 
• 10287-53-3 ethyl p-dimethyaminolbenzoate 
• 865-47-4 potassium tert-butylate 

Downstream Products

• 75784-67-7 C₁₂H₁₉NO₂Si 
• 1241978-78-8 4-[¹⁸F]-1,1-dimethylethyl ester benzoic acid 
• 10011-97-9 4-[¹⁸F]fluorobenzoic acid 
• 141762-27-8 N-succinimidyl 4-[18F]fluorobenzoate 

Relevant articles and documents

Ruthenium-catalyzed ester reductions applied to pharmaceutical intermediates

Ruthenium pincer complexes were synthesized and used for catalytic ester reductions under mild conditions (～5 bar of hydrogen). An experimental design approach was used to optimize the conditions for yield, purity, and robustness. Evidence for the catalytically active ruthenium dihydride species is presented. Observed intermediates and side products, as well as time-course data, were used to build mechanistic insight. The optimized procedure was further demonstrated through scaled-up reductions of two pharmaceutically relevant esters, both in batch and continuous flow.

PEPTIDOMIMETICS FOR IMAGING THE GHRELIN RECEPTOR

ABSTRACT The present invention concerns compositions comprising and methods of identification and use of imaging agents. The imaging agents comprise a growth hormone secretagogues having a conjugated fluoride. The imaging agents of the present invention may be used for detection, diagnosis and/or staging of prostate or other forms of cancer, and may also be used for cardiac disease.