7579-40-0

Basic information

• Product Name: benzyl 2-chlorobenzoate
• Synonyms: benzyl 2-chlorobenzoate
• CAS NO: 7579-40-0
• Molecular Formula: C₁₄H₁₁ClO₂
• Molecular Weight: 246.68894
• Mol File: 7579-40-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 356.2°Cat760mmHg
• Flash Point: 181.7°C
• Appearance: /
• Density: 1.233g/cm³
• Vapor Pressure: 2.96E-05mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: benzyl 2-chlorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 2-chlorobenzoate(7579-40-0)
• EPA Substance Registry System: benzyl 2-chlorobenzoate(7579-40-0)

Safety Data

• Hazardous Substances Data: 7579-40-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H11ClO2/c15-13-9-5-4-8-12(13)14(16)17-10-11-6-2-1-3-7-11/h1-9H,10H2

Upstream product

• 103-83-3 N,N'-dimethylbenzylamine 
• 610-96-8 methyl chlorobenzoate 
• 100-44-7 benzyl chloride 
• 118-91-2 ortho-chlorobenzoic acid 
• 100-39-0 benzyl bromide 
• 100-51-6 benzyl alcohol 
• 103-82-2 phenylacetic acid 
• 108-88-3 toluene 
• 89-98-5 2-chloro-benzaldehyde 
• 58824-52-5 α-vinyl-o-chlorobenzyl alcohol 
• 609-65-4 o-chlorobenzoyl chloride 

Downstream Products

• 118-91-2 ortho-chlorobenzoic acid 
• 620-47-3 1-methyl-3-(phenylmethyl)-benzene 
• 620-83-7 1-methyl-4-(phenylmethyl)benzene 
• 713-36-0 2-benzyltoluene 

Relevant articles and documents

Photochemical Activation of Aromatic Aldehydes: Synthesis of Amides, Hydroxamic Acids and Esters

A cheap, facile and metal-free photochemical protocol for the activation of aromatic aldehydes has been developed. Utilizing thioxanthen-9-one as the photocatalyst and cheap household lamps as the light source, a variety of aromatic aldehydes have been activated and subsequently converted in a one-pot reaction into amides, hydroxamic acids and esters in good to high yields. The applicability of this method was highlighted in the synthesis of Moclobemide, a drug against depression and social anxiety. Extended and detailed mechanistic studies have been conducted, in order to determine a plausible mechanism for the reaction.

Reusable ionic liquid-catalyzed oxidative esterification of carboxylic acids with benzylic hydrocarbons via benzylic Csp3-H bond activation under metal-free conditions

A metal-free protocol for the direct oxidative esterification of the Csp3-H bond in benzylic hydrocarbons with carboxylic acids using heterocyclic ionic liquid as catalyst has been reported. The catalyst 1-butylpyridinium iodide could be easily recycled and reused for at least four cycles without obvious loss of catalytic activity.

Convenient esterification of carboxylic acids by SN2 reaction promoted by a protic ionic-liquid system formed in situ in solvent-free conditions

The reaction of esterification of benzoic acid with benzyl chloride was chosen as a model reaction to study the esterification by SN2 promoted by tertiary amine as deprotonating agent. The use of ionic liquid (IL) 1,3-dimethylimidazolium methanesulfonate [MMIm][OMs] as reaction medium has proven to give quantitative yield of the ester, but interestingly the reaction does occur even in solvent-free conditions, where the acid + the amine form a liquid system (a protic IL) in situ. This last methodology was extended to several carboxylic acids in conditions of atom economy (i.e., without excess of any reagent), giving moderately good yields of esters (54-78%) recovered by weight in pure form.