757955-30-9Relevant articles and documents
Synthesis of medium ring heterocycles using an intramolecular Heck reaction
Arnold, Leggy A.,Luo, Wenchen,Guy, R. Kiplin
, p. 3005 - 3007 (2007/10/03)
(Equation Presented) Historically, general convergent syntheses of medium ring heterocycles have been difficult to develop. Herein, we describe the synthesis of five classes of heterocycles: dihydrodibenzo[b,f]azepine, -oxocine, and -thiocine and dibenzo[b,f]azepine and -oxepine using a strategy of alkylation followed by highly selective intramolecular Heck arylation reaction. The hetero-tricyclic compounds were available in only two steps starting from commercially available starting materials.