757976-25-3

Basic information

• Product Name: Carbamic acid, [(1R)-2-[(4-methoxyphenyl)amino]-1-methylethyl]-, 1,1-dimethylethyl ester
• CAS NO: 757976-25-3
• Molecular Formula: C15H24N2O3
• Molecular Weight: 280.367
• Mol File: 757976-25-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1R)-2-[(4-methoxyphenyl)amino]-1-methylethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R)-2-[(4-methoxyphenyl)amino]-1-methylethyl]-, 1,1-dimethylethyl ester(757976-25-3)
• EPA Substance Registry System: Carbamic acid, [(1R)-2-[(4-methoxyphenyl)amino]-1-methylethyl]-, 1,1-dimethylethyl ester(757976-25-3)

Safety Data

• Hazardous Substances Data: 757976-25-3(Hazardous Substances Data)

Upstream product

• 3744-87-4 Boc-(R)-Ala 
• 79069-13-9 (R)-2-tertbutoxycarbonylamino-1-propanol 
• 63228-64-8 N-(4'-methoxyphenyl)-2-nitrobenzenesulfonamide 
• 82353-56-8 (2R)-2-N-t-butoxycarbonyl-aminopropanal 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 757976-26-4 N¹-(4-methoxy-phenyl)-propane-1,2-diamine 

Relevant articles and documents

Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl

A systematic study of anilines led to the discovery of a metabolically robust fluoroindoline replacement for the alkoxy aniline toxicophore in 1. Investigations of the P1 pocket resulted in the discovery of a wide tolerance of functionality leading to the discovery of 11 as a potent and selective inhibitor of cathepsin S.

Potent and selective cathepsin K inhibitors

A novel series of cathepsin K inhibitors derived from Novartis compound I is described. Optimization of the P1, P3, and P1′ units led to the identification of 4-aminophenoxyacetic acid 24b with an IC50 value of 4.8 nM, which possessed an excell