757982-31-3

Basic information

• Product Name: 2-Fluoro-5-(Methoxycarbonyl)benzeneboronic acid pinacol ester, 96%
• Synonyms: 2-Fluoro-5-(Methoxycarbonyl)benzeneboronic acid pinacol ester, 96%;methyl 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate
• CAS NO: 757982-31-3
• Molecular Formula: C₁₄H₁₈BFO₄
• Molecular Weight: 298.1150032
• Mol File: 757982-31-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 100-102℃
• Appearance: /
• CAS DataBase Reference: 2-Fluoro-5-(Methoxycarbonyl)benzeneboronic acid pinacol ester, 96%(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-5-(Methoxycarbonyl)benzeneboronic acid pinacol ester, 96%(757982-31-3)
• EPA Substance Registry System: 2-Fluoro-5-(Methoxycarbonyl)benzeneboronic acid pinacol ester, 96%(757982-31-3)

Safety Data

• Hazardous Substances Data: 757982-31-3(Hazardous Substances Data)

Usage

General Description

The chemical compound "2-Fluoro-5-(Methoxycarbonyl)benzeneboronic acid pinacol ester, 96%" is a boronic acid derivative with a high purity of 96%. It is used in organic synthesis as a valuable building block for the preparation of various pharmaceuticals, agrochemicals, and organic materials. 2-Fluoro-5-(Methoxycarbonyl)benzeneboronic acid pinacol ester, 96% can be utilized in Suzuki-Miyaura cross-coupling reactions to form carbon-carbon bonds, making it a versatile tool in the production of complex molecules. Additionally, its high purity ensures consistent and reliable results in chemical reactions and applications.

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 82702-31-6 methyl 3-bromo-4-fluorobenzoate 
• 403-33-8 methyl 4-flurobenzoate 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 

Downstream Products

• 850568-04-6 (2-fluoro-5-(methoxycarbonyl)-phenyl)boronic acid 
• 403-33-8 methyl 4-flurobenzoate 
• 214822-96-5 4-Fluoro-3-hydroxy-benzoic acid methyl ester 

Relevant articles and documents

Sequential Ir/Cu-Mediated Method for the Meta-Selective C-H Radiofluorination of (Hetero)Arenes

This article describes a sequential Ir/Cu-mediated process for the meta-selective C-H radiofluorination of (hetero)arene substrates. In the first step, Ir-catalyzed C(sp2)-H borylation affords (hetero)aryl pinacolboronate (BPin) esters. The intermediate organoboronates are then directly subjected to copper-mediated radiofluorination with [18F]tetrabutylammonium fluoride to afford fluorine-18 labeled (hetero)arenes in high radiochemical yield and radiochemical purity. This entire process is performed on a benchtop without Schlenk or glovebox techniques and circumvents the need to isolate (hetero)aryl boronate esters. The reaction was automated on a TracerLab FXFN module with 1,3-dimethoxybenzene and a meta-tyrosine derivative. The products, [18F]1-fluoro-3,5-dimethoxybenzene and an 18F-labeled meta-tyrosine derivative, were obtained in 37 ± 5% isolated radiochemical yield and >99% radiochemical purity and 25% isolated radiochemical yield and 99% radiochemical purity, and 0.52 Ci/μmol (19.24 GBq/μmol) molar activity (Am), respectively.

Fluorine-controlled C-H borylation of arenes catalyzed by a PSiN-pincer platinum complex

An efficient, regioselective synthesis of fluorine-substituted arylboronic esters was achieved through fluorine-controlled C-H borylation of arenes with diboron catalyzed by a PSiN-platinum complex. The promising utility of the PSiN-platinum catalyst and its unique regioselectivity were demonstrated for the first time, which would complement the well-developed Ir-catalyzed C-H borylation.

(3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors

New (3-oxo)pyridazin-4-ylurea derivatives having the chemcial structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the phosphodiesterase IV (PDE4).