7583-84-8Relevant articles and documents
Heterogeneous ring-opening reactions and Knoevenagel condensation reactions with cobalt complexes: Effect of CoII versus CoIII states on catalysis
Kumar, Sushil,Gupta, Rajeev
, p. 843 - 852 (2020/06/26)
This work illustrates comparative catalytic performance of two sets of cobalt complexes within a common macrocyclic ligand environment: CoII complexes 1 and 2 versus CoIII complexes 3 and 4. All four cobalt complexes functioned as the heterogeneous catalysts for the ring-opening reactions of assorted epoxides as well as Knoevenagel condensation reactions of assorted aldehydes. Cobalt(II) complexes were noted to be the superior catalysts over cobalt(III) complexes for both types of organic transformations. The observed difference in the catalytic performance of two sets of cobalt complexes has been related to the kinetic differences between CoII versus CoIII ions. All four cobalt complexes display high catalytic efficiency and excellent reusability without any apparent loss in the catalytic performance.
In vivo antifilarial activity of some cyclic and acylic alcohols
Agarwal, Alka,Awasthi, Satish K.,Murthy
experimental part, p. 430 - 434 (2012/04/18)
The filarial nematodes, Wuchereria bancrofti, Brugia malayi, and Brugia timori are the causative agents of lymphatic filariasis. 2-Substituted propanol, cyclohexanol, and cyclooctanol compounds were evaluated for microfilaricidal and macrofilaricidal activity in vivo against Acanthocheilonema viteae and Litomosoides carinii in rodents. In the cyclohexanol series, 2-(piperidin-1-yl) cyclohexanol (2b) showed 88.9% macrofilaricidal activity against A. viteae in vivo, while cyclooctanol series, 2-(4- benzyl piperdin-1-yl) cyclooctanol (2f) showed 100% macrofilaricidal activity against A. viteae. Further, compounds 1-(furan-2-ylamino) ethanol (4a) and 1-(4-benzylpiperidin- 1-yl)-ethyl acetate (5b) showed 81.3% and 83.4% macrofilaricidal activity, respectively, against the same parasite. Interestingly, compounds 2f and 4a showed significant sterilization of female worms in A. viteae. However, these compounds were found inactive against L. carinii. Therefore, the new class of compounds appeared to have promising antifilarial activity.
Synthesis of nitrile coordinated Lewis acids Al(OC(CF3) 2R)3 and their application in catalytic epoxide ring-opening reactions
Li, Yang,Tan, Yi,Herdtweck, Eberhardt,Cokoja, Mirza,Kühn, Fritz E.
experimental part, p. 171 - 176 (2010/11/04)
Four nitrile ligated aluminum-based Lewis acids PhCNAl(OC(CF 3)2PhCH3)3 (1), CH 3CNAl(OC(CF3)2PhCH3)3 (2), PhCNAl(OC(CF3)2Ph)3 (3), CH 3CNAl(OC(CF3)2Ph)3 (4) were synthesized and characterized by nuclear magnetic resonance and infrared spectroscopy, as well as X-ray crystallography. The ring-opening reactions of epoxides with aromatic/aliphatic amines were efficiently catalyzed by compounds 1-4 as catalysts in a concentration of 1 mol% under solvent-free conditions at room temperature, affording 2-amino alcohols in high yields (up to 99%) within 4 h. Compound 1, being the best catalyst, yields 70% product within 10 min. Published by Elsevier B.V.
