75835-06-2Relevant articles and documents
Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
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, (2013/03/26)
The present invention relates to compounds defined by Formula (I), wherein the groups A, B, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
Bridged-ring Nitrogen Compounds. Part 3. Synthesis of Representatives of the 1,5-Methano-4-benzazonine Ring System
Smith, Francis J.,Proctor, George R.
, p. 2141 - 2145 (2007/10/02)
Reaction of arylaldehydes with 2,4-dimethylpyridine and n-butyl-lithium gives in good yield 1-aryl-2-(4-methylpyridyl)ethanols which, after dehydration with polyphosphoric acid and catalytic hydrogenation, give 2-phenethyl-4-methylpyridines.Cyclisation of
