7584-09-0

Basic information

• Product Name: 2-Cyano-3,5-dimethylpyridine
• Synonyms: 2-Cyano-3,5-dimethylpyridine;3,5-Dimethylpyridine-2-carbonitrile;2-Cyano-3,5-dimethylpyridine, 3,5-Dimethylpicolinonitrile;5-diMethylpyridine-2-carbonitrile;4,6-DiMethylpicolinonitrile;3,5-DiMethylpyridine-2-carbonitrile 97%;3,5-dimethylpicolinonitrile
• CAS NO: 7584-09-0
• Molecular Formula: C8H8N2
• Molecular Weight: 132.16252
• Product Categories: Heterocyclic Compounds;C7 and C8;Heterocyclic Building Blocks;Pyridines
• Mol File: 7584-09-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 58-62 °C
• Boiling Point: 283.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.05±0.1 g/cm3(Predicted)
• PKA: 0.26±0.20(Predicted)
• CAS DataBase Reference: 2-Cyano-3,5-dimethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyano-3,5-dimethylpyridine(7584-09-0)
• EPA Substance Registry System: 2-Cyano-3,5-dimethylpyridine(7584-09-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 7584-09-0(Hazardous Substances Data)

Usage

General Description

2-Cyano-3,5-dimethylpyridine, also known as DMAP or 4-dimethylaminopyridine, is a widely used chemical compound in organic synthesis. It is a highly reactive nucleophilic catalyst that is often used as a catalyst in the esterification and acylation reactions, as well as in the synthesis of pharmaceuticals and specialty chemicals. DMAP is a white crystalline solid with a slightly fishy odor, and it is highly soluble in organic solvents such as acetone, ether, and benzene. It is known for its ability to promote reactions under mild conditions and for its versatility in a wide range of chemical transformations, making it a valuable tool in the field of organic chemistry.

Upstream product

• 591-22-0 3,5-Lutidine 
• 151-50-8 potassium cyanide 

Downstream Products

• 1407185-43-6 1-(3,5-dimethylpyridin-2-yl)-2-(1-methyl-2-oxo-2-phenylethylsulfanyl)propan-1-one 
• 1407185-44-7 C₁₉H₂₀N₂O₂S 
• 780801-80-1 (3,5-dimethylpyridin-2-yl)methanamine 

Relevant articles and documents

Preparation of cyanopyridines by direct cyanation

After pretreatment with nitric acid and trifluoroacetic anhydride, aqueous potassium cyanide converted pyridines 1a-1 into their corresponding 2-cyano derivatives 4a-1 in an average yield of 52%. Georg Thieme Verlag Stuttgart.

Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of Formula 1.0 STR1 Also disclosed are novel compounds of the formulas: STR2 Also disclosed are processes for making 3-substituted compounds of the Formulas 1.1, 1.2 and 1.3. Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formulas 1.1, 1.2, and 1.3.

Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Novel compounds of Formula (7.0a), (7.0b) or (7.0c): STR1 are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the formula (7.0a), (7.0b) or (7.0c) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.