758670-88-1

Basic information

• Product Name: 4'-(2-{[2-(3-fluorophenyl)-2-hydroxyethyl]amino}ethyl)-2-(2-pyridyl)acetanilide
• CAS NO: 758670-88-1
• Molecular Weight: 393.461
• Mol File: 758670-88-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4'-(2-{[2-(3-fluorophenyl)-2-hydroxyethyl]amino}ethyl)-2-(2-pyridyl)acetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-(2-{[2-(3-fluorophenyl)-2-hydroxyethyl]amino}ethyl)-2-(2-pyridyl)acetanilide(758670-88-1)
• EPA Substance Registry System: 4'-(2-{[2-(3-fluorophenyl)-2-hydroxyethyl]amino}ethyl)-2-(2-pyridyl)acetanilide(758670-88-1)

Safety Data

• Hazardous Substances Data: 758670-88-1(Hazardous Substances Data)

Upstream product

• 18511-63-2 3-fluorophenylethylene oxide 

Relevant articles and documents

Synthesis and evaluation of novel phenylethanolamine derivatives containing acetanilides as potent and selective b 3-adrenergic receptor agonists

In the search for potent and selective human β3-adrenergic receptor (AR) agonists as potential pharmacotherapies for the treatment of obesity and non-insulin dependent (type II) diabetes, we prepared a novel series of phenylethanolamine derivatives containing acetanilides and evaluated their biological activities at the human β3-, β2-, and β1-ARs. Among these compounds, the 6-amino-2-pyridylacetanilide (36b), 2-amino-5- methylthiazol- 4-ylacetanilide (36g), and 5-amino-1,2,4-thiadiazol-3- ylacetanilide (36h) derivatives showed potent agonistic activity at the β3-AR with functional selectivity over the β1- and β2-ARs. In addition, these compounds exhibited significant hypoglycemic activity in a rodent diabetic model.