75869-37-3

Basic information

• Product Name: 5,7-bis(1,1-dimethylethyl)-3-(4-methoxyphenyl)-(3H)-benzofuran-2-one
• Synonyms: 5,7-bis(1,1-dimethylethyl)-3-(4-methoxyphenyl)-(3H)-benzofuran-2-one;3-(4-Methoxyphenyl)-5,7-di-tert-butylbenzofuran-2(3H)-one;5,7-Bis(1,1-dimethylethyl)-3-(4-methoxyphenyl)-2(3H)-benzofuranone;5,7-Di-tert-butyl-3-(4-methoxyphenyl)benzofuran-2(3H)-one
• CAS NO: 75869-37-3
• Molecular Formula: C₂₃H₂₈O₃
• Molecular Weight: 352.46662
• EINECS: 278-330-1
• Mol File: 75869-37-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5,7-bis(1,1-dimethylethyl)-3-(4-methoxyphenyl)-(3H)-benzofuran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-bis(1,1-dimethylethyl)-3-(4-methoxyphenyl)-(3H)-benzofuran-2-one(75869-37-3)
• EPA Substance Registry System: 5,7-bis(1,1-dimethylethyl)-3-(4-methoxyphenyl)-(3H)-benzofuran-2-one(75869-37-3)

Safety Data

• Hazardous Substances Data: 75869-37-3(Hazardous Substances Data)

Upstream product

• 100-66-3 methoxybenzene 
• 163489-63-2 5,7-di-tert-butyl-3-hydroxy-3H-benzofuran-2-one 
• 96-76-4 2,4-di-tert-Butylphenol 

Relevant articles and documents

Sequential Continuous-Flow Synthesis of 3-Aryl Benzofuranones

A sequential continuous-flow system to produce 3-aryl benzofuranones was developed. Starting from 2,4-di-tert-butylphenol and glyoxylic acid monohydrate, both the initial cyclocondensation and the subsequent Friedel?Crafts alkylation were catalyzed by the same heterogeneous catalyst, Amberlyst-15H. The catalyst has a promising life-time for these two steps, and it was able to be recovered and reused for several runs without deactivation. By using the established flow system, 5,7-di-tert-butyl-3-(3,4-dimethylphenyl)-3H-benzofuran-2-one (Irganox HP-136), which is a commercial antioxidant, was prepared in 88% two-step yield. Reactions with various aromatic compounds proceeded well under flow conditions to afford 3-aryl benzo-furanone derivatives in high yields with good functional group compatibility.