758722-59-7

Basic information

• Product Name: prednisolone-21-O-β-carbonylpropionic acid p-nitrophenolic ester
• Synonyms: prednisolone-21-O-β-carbonylpropionic acid p-nitrophenolic ester
• CAS NO: 758722-59-7
• Molecular Weight: 581.62
• Mol File: 758722-59-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: prednisolone-21-O-β-carbonylpropionic acid p-nitrophenolic ester(CAS DataBase Reference)
• NIST Chemistry Reference: prednisolone-21-O-β-carbonylpropionic acid p-nitrophenolic ester(758722-59-7)
• EPA Substance Registry System: prednisolone-21-O-β-carbonylpropionic acid p-nitrophenolic ester(758722-59-7)

Safety Data

• Hazardous Substances Data: 758722-59-7(Hazardous Substances Data)

Upstream product

• 50-24-8 prednisolon 
• 100-02-7 4-nitro-phenol 
• 2920-86-7 prednisolone hemisuccinate 

Relevant articles and documents

The synthesis and immunosuppressive activities of steroid-urotoxin linkers

The urotoxins (Glu-Asp-Gly-OH, His-Gly-Glu-OH, His-Gly-Lys-OH, and His-Gly-Lys-NHNH2) were introduced into the convenient sites of hydrocortisone and prednisolone via the amidation or condensation reactions to form the corresponding linkers 7a-d, 8a-d, 9a,b, and 10a,b in acceptable yields. The bioassays such as prolongation of heterotopic transplanted cardiac tissue survival in vivo, inhibitory effects on phagocytosis of mouse peritoneal macrophages and concanavalin (ConA) or lipopolysaccharide (LPS) induced proliferation of mouse spleen lymphocytes in vitro show that at the comparable concentrations the immunosuppressive activities of the steroid-urotoxin linkers 7a-d, 8a-d, 9a,b, and 10a,b were higher than that of hydrocortisone, prednisolone, and the urotoxins alone, as well as significantly higher than that of the mixture of hydrocortisone and urotoxins or prednisolone and urotoxins. The so-called 'permissive action' may be responsible for the enhancement of the mentioned bioactivities of the steroid-urotoxin linkers 7a-d, 8a-d, 9a,b, and 10a,b.