75910-81-5

Basic information

• Product Name: α-cyano-3-methoxyphenylacetic acid ethyl ester
• Synonyms: α-cyano-3-methoxyphenylacetic acid ethyl ester
• CAS NO: 75910-81-5
• Molecular Weight: 219.24
• Mol File: 75910-81-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: α-cyano-3-methoxyphenylacetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: α-cyano-3-methoxyphenylacetic acid ethyl ester(75910-81-5)
• EPA Substance Registry System: α-cyano-3-methoxyphenylacetic acid ethyl ester(75910-81-5)

Safety Data

• Hazardous Substances Data: 75910-81-5(Hazardous Substances Data)

Upstream product

• 2398-37-0 3-methoxyphenyl bromide 
• 105-56-6 ethyl 2-cyanoacetate 
• 766-85-8 3-methoxy-1-iodobenzene 
• 19924-43-7 3-methoxyphenylacetonitrile 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 26056-32-6 2-(3-anisyl)-3-methylbutanonitrile 
• 1627110-74-0 ethyl 2-cyano-2-(3-methoxy-4-(perfluorohexyl)phenyl)acetate 
• 1627110-75-1 ethyl 2-cyano-2-(5-methoxy-2-(perfluorohexyl)phenyl)acetate 
• 1627110-76-2 ethyl 2-cyano-2-(5-methoxy-2,4-bis(perfluorohexyl)phenyl)acetate 
• 1627110-77-3 ethyl 2-cyano-2-(3-methoxy-2-(perfluorohexyl)phenyl)acetate 
• 1359840-98-4 ethyl 3-amino-2-benzyl-2-(3-methoxyphenyl)propanoate hydrochloride 
• 1359840-97-3 ethyl 2-cyano-2-(3-methoxyphenyl)-3-phenylpropanoate 
• 1344688-96-5 C₂₁H₁₉NO₅ 
• 1344688-60-3 C₁₉H₁₅NO₅ 
• 1344688-91-0 C₂₁H₂₁NO₄ 
• 1344688-74-9 C₂₁H₂₃NO₄ 
• 1344688-67-0 C₂₁H₂₅NO₅ 
• 79987-71-6 2-(3-methoxyphenyl)glutaric acid 
• 85858-95-3 7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid 

Relevant articles and documents

Arylation of diethyl malonate and ethyl cyanoacetate catalyzed by palladium/di-tert-butylneopentylphosphine

α-Arylated carbonyl derivatives are important structural motifs in many natural products and pharmaceutically active compounds. Although arylation of simple monocarbonyl compounds is a well-established methodology, metal-catalyzed arylation of β-dicarbonyl derivatives is significantly more challenging. The ability of β-dicarbonyl anions to bind to palladium in a κ2-O,O mode, rather than the κ1-C-bound mode required for bond formation, often results in the deactivation of catalyst systems. The C-bound form of the enolate can be favored through the use of sterically demanding ligands. Herein, we report that the sterically demanding di-tert-butylneopentylphosphine (DTBNpP) ligand in combination with Pd(dba)2 provides an effective catalyst for the coupling of aryl bromides and chlorides with diethyl malonate. The Pd/DTBNpP system also catalyzes the coupling of aryl bromides with ethyl cyanoacetate.

PHENALKYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY

The present invention relates to phenalkylamine derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such phenalkylamine derivatives, and the use of such phenalkylamine

Synthesis of substituted isoquinolines via Pd-catalyzed cross-coupling approaches

Palladium complexes incorporating ligands based on a 1,3,5,7-tetramethyl-2, 4,8-trioxa-6-phosphaadamantanyl scaffold were used to catalyze the arylation of ethyl cyanoacetate, malononitrile, and various ketones. The products from these reactions can be el