75933-81-2

Basic information

• Product Name: 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁴-benzoylcytidine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate)
• Synonyms: 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁴-benzoylcytidine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate)
• CAS NO: 75933-81-2
• Molecular Weight: 1085.93
• Mol File: 75933-81-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁴-benzoylcytidine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate)(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁴-benzoylcytidine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate)(75933-81-2)
• EPA Substance Registry System: 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁴-benzoylcytidine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate)(75933-81-2)

Safety Data

• Hazardous Substances Data: 75933-81-2(Hazardous Substances Data)

Upstream product

• 69359-38-2 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁴-benzoylcytidine 
• 130-16-5 5-Chloro-8-hydroxyquinoline 
• 772-79-2 4-chlorophenylphosphorodichloridate 
• 77181-80-7 Phosphorochloridic acid 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester 
• 77181-81-8 4-chlorophenyl 5-chloro-8-quinolyl phosphorotetrazolide 
• 81366-72-5 4-chlorophenyl 5-chloro-8-quinolyl hydrogen phosphate 

Downstream Products

• 78462-57-4 Phosphoric acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with pyridine 
• 76963-61-6 C₈₂H₇₁ClN₉O₁₈P 
• 75933-85-6 C₅₁H₄₇ClN₄O₁₂P^(1-) 
• 75933-89-0 Phosphoric acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester 
• 71933-72-7 Phosphoric acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester 
• 75933-85-6 C₄₈H₄₆ClN₃O₁₂P^(1-) 

Relevant articles and documents

4-CHLOROPHENYL 5-CHLORO-8-QUINOLYL HYDROGEN PHOSPHATE: A USEFUL PHOSPHORYLATING AGENT FOR GUANOSINE 3'-PHOSPHOTRIESTER

5'-O-Dimethoxytrityl-2'-O-tetrahydropyranyl-N2-benzoylguanosine smoothly reacts with 4-chlorophenyl 5-chloro-8-quinolyl hydrogen phosphate in the presence of 8-quinolinesulfonyltetrazolide (QS-te) to give 5'-O-dimethoxytrityl-2'-O-tetrahydropyr

4-CHLOROPHENYL 5-CHLORO-8-QUINOLYL PHOSPHOROCHLORIDATE: A PRACTICALLY USEFUL PHOSPHORYLATING AGENT FOR OLIGORIBONUCLEOTIDE SYNTHESIS VIA PHOSPHOTRIESTER APPROACH

5'-O-Dimethoxytrityl-2'-O-tetrahydropyranylnucleosides (2) smoothly reacts with 4-chlorophenyl 5-chloro-8-quinolyl phosphorochloridate (1) prepared form 4-chlorophenyl phosphodichloridate and 5-chloro-8-hydroxyquinoline to give 5'-O-dimethoxytrityl-2'-O-tetrahydropyranylnucleoside 3'-(4-chlorophenyl, 5-chloro-8-quinolyl) phosphates (3) in high yields.They are key intermediates for the synthesis of oligoribonucleotides via phosphotriester approach.

(8-Quinolinesulfonyl)tetrazole: A New Type of Highly Efficient Coupling Agent for the Synthesis of Ribooligonucleotides by the Phosphortriester Approach

(8-Quinolinesulfonyl)Tetrazole (QS-tet) has been developed as a new type of highly efficient coupling agent in the synthesis of phosphotriester bonds.This reagent very rapidly completes the coupling reactions, and the yield is considerably higher than tha