7595-68-8

Basic information

• Product Name: BenzaMide, 3-nitro-N-(phenylMethyl)-
• Synonyms: BenzaMide, 3-nitro-N-(phenylMethyl)-
• CAS NO: 7595-68-8
• Molecular Formula: C₁₄H₁₂N₂O₃
• Molecular Weight: 256.25668
• Mol File: 7595-68-8.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 468.9°Cat760mmHg
• Flash Point: 237.4°C
• Appearance: /
• Density: 1.266g/cm³
• Vapor Pressure: 5.78E-09mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: BenzaMide, 3-nitro-N-(phenylMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzaMide, 3-nitro-N-(phenylMethyl)-(7595-68-8)
• EPA Substance Registry System: BenzaMide, 3-nitro-N-(phenylMethyl)-(7595-68-8)

Safety Data

• Hazardous Substances Data: 7595-68-8(Hazardous Substances Data)

Usage

General Description

Benzamide, 3-nitro-N-(phenylmethyl)- is a chemical compound that consists of a benzene ring attached to an amide group and a 3-nitro group. It is commonly used in the pharmaceutical industry as a building block for the synthesis of various compounds, including pharmaceutical drugs. The 3-nitro group on the benzamide molecule can confer specific properties and reactivity to the compound. This chemical has potential applications in drug discovery and development, as well as in medicinal chemistry research. It is important to handle and use this chemical with caution, following proper safety protocols and guidelines.

InChI:InChI=1/C14H12N2O3/c17-14(15-10-11-5-2-1-3-6-11)12-7-4-8-13(9-12)16(18)19/h1-9H,10H2,(H,15,17)

Upstream product

• 618-95-1 methyl 3-nitrobenzoate 
• 100-46-9 benzylamine 
• 618-98-4 ethyl 3-nitrobenzoate 
• 121-92-6 3-nitrobenzoic acid 
• 805316-33-0 N-Benzyl-1-(3-nitrophenyl)methanimine 
• 121-90-4 m-nitrobenzoic acid chloride 
• 622-79-7 benzyl azide 
• 99-61-6 3-nitro-benzaldehyde 
• 29237-95-4 chloro-benzyl amine 
• 645-09-0 3-nitrobenzamide 

Downstream Products

• 54977-91-2 3-amino-N-benzylbenzamide 

Relevant articles and documents

Photochemical Activation of Aromatic Aldehydes: Synthesis of Amides, Hydroxamic Acids and Esters

A cheap, facile and metal-free photochemical protocol for the activation of aromatic aldehydes has been developed. Utilizing thioxanthen-9-one as the photocatalyst and cheap household lamps as the light source, a variety of aromatic aldehydes have been activated and subsequently converted in a one-pot reaction into amides, hydroxamic acids and esters in good to high yields. The applicability of this method was highlighted in the synthesis of Moclobemide, a drug against depression and social anxiety. Extended and detailed mechanistic studies have been conducted, in order to determine a plausible mechanism for the reaction.

Amidation and esterification of carboxylic acids with amines and phenols by N,N′-diisopropylcarbodiimide: A new approach for amide and ester bond formation in water

The present study reports the successful synthesis of two important and abundant functional groups “ester and amide” by N,N′-diisopropylcarbodiimide (DIC) in water as a green solvent. A wide range of substrates could be employed with high functional group tolerance. The products were obtained in high yields after short reaction times. This method provides an efficient, economic, simple and very mild protocol for ester and amide bond formation in aqueous media. In addition, this work not only may lead to environmentally benign systems but also will provide a new aspect of organic chemistry in water.

Poly(methylhydrosiloxane) as a green reducing agent in organophosphorus-catalysed amide bond formation

Development of catalytic amide bond formation reactions has been the subject of the intensive investigations in the past decade. Herein we report an efficient organophosphorus-catalysed amidation reaction between unactivated carboxylic acids and amines. Poly(methylhydrosiloxane), a waste product of the silicon industry, is used as an inexpensive and green reducing agent for in situ reduction of phosphine oxide to phosphine. The reported method enables the synthesis of a wide range of secondary and tertiary amides in very good to excellent yields.