7597-47-9

Basic information

• Product Name: methyl 3-(4-nitrophenyl)sulfanylpropanoate
• Synonyms: methyl 3-(4-nitrophenyl)sulfanylpropanoate
• CAS NO: 7597-47-9
• Molecular Formula: C₁₀H₁₁NO₄S
• Molecular Weight: 241.26
• Mol File: 7597-47-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 379.8°C at 760 mmHg
• Flash Point: 183.5°C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 5.69E-06mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: methyl 3-(4-nitrophenyl)sulfanylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(4-nitrophenyl)sulfanylpropanoate(7597-47-9)
• EPA Substance Registry System: methyl 3-(4-nitrophenyl)sulfanylpropanoate(7597-47-9)

Safety Data

• Hazardous Substances Data: 7597-47-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11NO4S/c1-15-10(12)6-7-16-9-4-2-8(3-5-9)11(13)14/h2-5H,6-7H2,1H3

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 1849-36-1 para-nitrobenzenethiol 
• 2935-90-2 Methyl 3-mercaptopropionate 
• 15959-31-6 sodium 4-nitrobenzenesulfinate 
• 100-25-4 para-dinitrobenzene 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 131042-40-5 methyl 3-<(4-aminophenyl)thio>propanoate 
• 138234-46-5 (+/-)-Methyl 3-<(4-nitrophenyl)sulfinyl>propanoate 
• 114426-32-3 3-<(4-Nitrophenyl)sulfinyl>propanoic acid 
• 138234-47-6 (S)-(-)-3-<(4-Nitrophenyl)sulfinyl>propanoic acid 
• 131042-44-9 methyl 3-<<4-(ethylamino)phenyl>thio>propanoate 
• 131042-46-1 3-<<4-<(2-chloroethyl)ethylamino>phenyl>thio>propanoic acid 
• 131042-45-0 methyl 3-<<4-<(2-chloroethyl)ethylamino>phenyl>thio>propanoate 
• 131042-39-2 methyl 3-<<4-phenyl>thio>propanoate 
• 131042-41-6 methyl 3-<<4-(trifluoroacetamido)phenyl>thio>propanoate 
• 131042-43-8 methyl 3-<<4-(N-ethyltrifluoroacetamido)phenyl>thio>propanoate 

Relevant articles and documents

Transition Metal-Free C-H Thiolation via Sulfonium Salts Using β-Sulfinylesters as the Sulfur Source

We disclose a direct C(sp)-, C(sp2)-, and C(sp3)-H thiolation reaction using β-sulfinylesters as the versatile sulfur source. The key step of this protocol is chemoselective C-S bond cleavage of the sulfonium salts that are formed in situ from the corresponding alkenes, alkynes, and 1,3-dicarboxyl compounds with β-sulfinylesters. The successful capture of the acrylate byproduct supports a retro-Michael reaction mechanism.

C-S coupling with nitro group as leaving group via simple inorganic salt catalysis

An efficient and practical synthetic protocol to synthesize nonsymmetrical aryl thioethers by nucleophilic aromatic substitution (SNAr) reaction of nitroarenes by thiols with potassium phosphate as the catalyst is described. Various moderate to strong electron-withdrawing functional groups are tolerated by the system to provide thioethers in a good to excellent yields. We also showed that the present method allows access to 3 drug examples in a short reaction time. Finally, mechanistic studies suggest that the reaction may form the classic Meisenheimer complex through a two-step addition-elimination mechanism.

Borax as an efficient metal-free catalyst for hetero-Michael reactions in an aqueous medium

Borax, a naturally occurring material, very efficiently catalyzed the conjugate addition of thiols, dithiols and amines to α,β-unsaturated ketones, nitriles, amides, aldehydes and esters in an aqueous medium to afford the corresponding Michael adducts in good yields at room temperature. Recycling of the catalyst and scaling up of the reactions are important attributes of this catalysis. The reactions of thiols and dithiols were relatively more facile than those of the corresponding amines. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.