75987-08-5

Basic information

• Product Name: 2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid
• Synonyms: 2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid
• CAS NO: 75987-08-5
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.3
• Mol File: 75987-08-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 437.9°C at 760 mmHg
• Flash Point: 218.6°C
• Appearance: /
• Density: 1.183g/cm³
• Vapor Pressure: 1.93E-08mmHg at 25°C
• Refractive Index: 1.624
• CAS DataBase Reference: 2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid(75987-08-5)
• EPA Substance Registry System: 2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid(75987-08-5)

Safety Data

• Hazardous Substances Data: 75987-08-5(Hazardous Substances Data)

Usage

General Description

2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid is a chemical compound with the molecular formula C19H17NO2. It is a derivative of the amino acid phenylalanine and is commonly known as febuxostat. Febuxostat is a xanthine oxidase inhibitor that is used to treat symptoms of gout by lowering the levels of uric acid in the blood. It works by blocking the action of xanthine oxidase, the enzyme responsible for the production of uric acid. Febuxostat is available in oral tablet form and is typically prescribed for long-term management of chronic gout. It is important to follow the prescribed dosage and instructions when using febuxostat to prevent potential side effects and interactions with other medications.

InChI:InChI=1/C16H15NO2/c1-12(16(18)19)9-13-4-6-14(7-5-13)10-15-3-2-8-17-11-15/h2-9,11H,10H2,1H3,(H,18,19)/b12-9+

Upstream product

• 75986-35-5 (E)-2-methyl-3-[4-(pyridin-3-ylmethyl)phenyl]acrylic acid ethyl ester 
• 6959-48-4 3-chloromethylpyridinium chloride 
• 75986-15-1 4-Pyridin-3-ylmethyl-benzaldehyde 
• 133292-05-4 4-(diethoxymethyl)phenylmagnesium bromide 
• 75986-14-0 4-(3-pyridylmethyl)benzaldehyde diethyl acetal 

Relevant articles and documents

Pyridine derivatives

The pyridine derivatives of the general formula: STR1 [wherein A represents an alkylene group containing from 1 to 5 carbon atoms unsubstituted or substituted by a hydroxy group, B represents a single bond, or an oxygen or sulphur atom, or an alkylene group containing from 1 to 5 carbon atoms, D represents a single bond, or an alkylene group containing from 1 to 5 carbon atoms, R represents a grouping of the formula: STR2 (in which R6 represents a hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms), Z represents a single bond, or an ethynylene group, or a grouping of the formula: STR3 in which R2 represents a hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms, R3 represents a hydrogen, bromine or chlorine atom, or an alkyl group containing from 1 to 4 carbom atoms; the symbol represents a single or double bond, the carbon atom attached to R2 binds to B, and the carbon atom attached to R3 binds to D, R1 represents a hydroxy group, or a grouping of the formula: --COOR4 or --COSR4, in which R4 represents a hydrogen atom, or an alkyl group containing from 1 to 12 carbon atoms, or an aralkyl group containing from 7 to 13 carbon atoms, or a cycloalkyl group containing from 4 to 7 carbon atoms unsubstituted or substituted by at least one alkyl group containing from 1 to 4 carbon atoms, or a phenyl unsubstituted or substituted by at least one halogen atom, trifluoromethyl group, alkyl or alkoxy or alkylthio group containing from 1 to 4 carbon atoms, nitro or phenyl group, R5 represents a hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms, with the proviso that, when B represents an oxygen or sulphur atom, Z represents a single bond and D represents an alkylene group containing from 1 to 5 carbon atoms], and non-toxic acid addition salts thereof and, when R1 represents a carboxy or thiocarboxy group, non-toxic salts thereof, possess a strong inhibitory activity on thromboxane synthetase from rabbit platelet microsomes, and are useful as therapeutically active agents in the prevention or treatment of inflammation, hypertension, thrombus, cerebral apoplexy, asthma, myocardial infarction, cardiostenosis, cerebral infarction and acute cardiac death.