76-74-4 Usage
Description
Pentobarbital (CRM) (Item No. 20966) is a certified reference material categorized as a barbiturate. Pentobarbital is regulated as a Schedule II compound in the United States. Pentobarbital (CRM) (Item No. 20966) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Chemical Properties
A white or almost white, crystalline powder or colourless crystals
Uses
Sedative-hypnotic.
Definition
ChEBI: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Brand name
Nembutal(Ovation)[Name previously used: Pentobarbitone.];Aethaminalum;Barbityral;Barbopent;Burtylonel;Cafergot p.b.;Calpental;Di-barbs;Dipental;Distonocalm;Ergobel plus;Hypnol;Hypnotal;Hyptonal;Insom rapido;Isoamytal;Isom rapido;Iturate;Narcoren;Nembudeine;Nicaphlogyl;Novarectal;Nova-rectal;Novopentobarb;Novo-pentobarb;Or-trin;Palpent;Pembul;Penbon;Pentalgin;Pentanca;Pentodormol;Pentogen;Pentolos;Petab;Petonel;Praecicalm;Prodormol;Somnophyt;Somnotol;S-spac;Stopp-15;Wans;Wigraine-pb;Yastyl.
World Health Organization (WHO)
Pentobarbital is a short-acting barbiturate which is controlled
under Schedule III of the 1971 Convention on Psychotropic Substances. See WHO
comment for barbiturates.
(Reference: (UNCPS3) United Nations Convention on Psychotropic Substances (III),
, , 1971)
Purification Methods
A solution of the sodium salt in 10% HCl is prepared, and the acid is extracted with ether. Evaporation of the extract gives a solid which is then purified by repeated crystallisation from CHCl3. It sublimes at 95-105o/10-12mm. [Bucket & Sandorfy J Phys Chem 88 3274 1984.] The (+)-and (-)-enantiomers crystallise from 50% aqueous EtOH with m 120-121o and have [] 25 +4.73o to –4.93o (EtOH) [Kleiderer & Shonle J Am Chem Soc 56 1772 1934]. [Beilstein 24
Check Digit Verification of cas no
The CAS Registry Mumber 76-74-4 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 76-74:
(4*7)+(3*6)+(2*7)+(1*4)=64
64 % 10 = 4
So 76-74-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H18N2O3/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
76-74-4Relevant articles and documents
Barbituric acid derivatives. 4. Relative configuration of opt. active pentobarbital, vinylbital and thiopental
Knabe,Geismar
, p. 682 - 685 (1968)
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5-ethyl-5 - (1-methyl butyl) method for preparing malonyl urea (by machine translation)
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Paragraph 0030; 0031, (2016/12/12)
The invention belongs to the technical field of drug synthesis, in particular relates to a 5-ethyl-5 - (1-methyl butyl) method for preparing malonyl urea. Ethyl malonic acid diethyl ester (III) with ethanol after the reaction ethanol solution of sodium in toluene in the presence of a mixture of the methanesulfonic acid (2-pentyl) should be ester instead, rectification to get ethyl-(1-methyl butyl) malonic acid diethyl ester compound (II); compound (II) in the presence of a methanol solution of sodium methoxide reaction with urea, acidified by hydrochloric acid, is recrystallized to get 5-ethyl-5 - (1-methyl butyl) malonyl urea fine (I). The process of the invention is stable, mild reaction conditions, is easy to control, the resulting product has high purity, high yield, the conversion is almost 100%, after treatment is simple and convenient, low energy consumption, little three waste, the mother liquor can be used continuously, low production cost, is suitable for industrial production. (by machine translation)
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