76006-17-2Relevant articles and documents
(AZA)PYRIDOPYRAZOLOPYRIMIDINONES AND INDAZOLOPYRIMIDINONES AS INHIBITORS OF FIBRINOLYSIS
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Page/Page column 66, (2015/05/26)
The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
Synthesis, reactivity and 13C-NMR of 1H-pyrazolo[3,4-c]pyridine derivatives
Milhavet, Jean-Claude,Gueiffier, Alain,Bernal, Lysiane,Teulade, Jean-Claude
, p. 1661 - 1667 (2007/10/03)
The synthesis of various 1H-pyrazolo [.-c.]pyridines was reported. 3- Cyano derivatives were obtained from the corresponding nitro compounds by Sandmeyer Reaction using Na3[Cu(CN)4] at pH 1. The 13C-NMR data of this series were also described.
Pyrazolopyridines. Part 5. Preparation and Reactions of Pyrazolopyridines
Chapman, David,Hurst, Jim
, p. 2398 - 2404 (2007/10/02)
A series of pyrazolopyridines has been prepared by nitrosation of 3-acetamido-4-methylpyridines and subsequent rearrangement and cyclisation of the N-acetyl-N-nitroso-compounds produced.The reactions of the pyrazolopyridines have been investigated. 1- and 2-Acetyl and 1- and 2-benzyl compounds were obtained and their structures elucidated spectroscopically.The ring system readily undergoes electrophilic substitution in the 3-position. 7-Chloropyrazolopyridine has been shown to be more susceptible to nucleophilic substitution than the isomeric 5-chloro-compound.