76006-33-2 Usage
Description
3-Bromo-2-methylbenzoic acid is a disubstituted benzoic acid derivative, characterized by the presence of a bromine atom at the 3rd position and a methyl group at the 2nd position on the benzene ring. It is a white to orange or brown powder in appearance and is known for its versatile applications in the synthesis of various biologically active compounds.
Uses
Used in Pharmaceutical Industry:
3-Bromo-2-methylbenzoic acid is used as a key intermediate in the synthesis of α-2 adrenoceptor agonists, which are important for the treatment of various medical conditions such as hypertension, anxiety, and depression. These agonists work by stimulating the α-2 adrenergic receptors, leading to a decrease in heart rate and blood pressure.
3-Bromo-2-methylbenzoic acid is also used as a precursor in the preparation of Smoothened receptor antagonists. These antagonists play a crucial role in the treatment of various cancers by targeting the Hedgehog signaling pathway, which is often dysregulated in cancer cells.
Furthermore, 3-Bromo-2-methylbenzoic acid is utilized in the development of HIV-1 entry inhibitors. These inhibitors are designed to prevent the human immunodeficiency virus (HIV) from entering and infecting host cells, thus helping to control the progression of the disease.
Used in Chemical Synthesis:
3-Bromo-2-methylbenzoic acid may be used to synthesize 4-(bromoacetyl)isoindolin-1-one and isocoumarins. These compounds have potential applications in various fields, including pharmaceuticals, materials science, and chemical research. The synthesis of these compounds from 3-Bromo-2-methylbenzoic acid demonstrates its versatility as a starting material for the preparation of diverse chemical entities.
Check Digit Verification of cas no
The CAS Registry Mumber 76006-33-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,0,0 and 6 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 76006-33:
(7*7)+(6*6)+(5*0)+(4*0)+(3*6)+(2*3)+(1*3)=112
112 % 10 = 2
So 76006-33-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H7BrO2/c1-5-6(8(10)11)3-2-4-7(5)9/h2-4H,1H3,(H,10,11)
76006-33-2Relevant articles and documents
MALT1 MODULATORS AND USES THEREOF
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Paragraph 00120; 00156, (2021/07/10)
Provided herein are compounds, compositions, and methods useful for modulating MALT1 and for treating related diseases, disorders, and conditions.
BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY
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Paragraph 0673; 0674; 0675, (2020/05/21)
The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
MUTANT RECEPTORS AND THEIR USE IN A NUCLEAR RECEPTOR-BASED INDUCIBLE GENE EXPRESSION SYSTEM
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Paragraph 0273; 0274, (2015/11/10)
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear
