76059-99-9Relevant articles and documents
Nucleophilic α-arylation and α-alkylation of ketones by polarity inversion of N-alkoxyenamines: Entry to the umpolung reaction at the α-carbon position of carbonyl compounds
Miyoshi, Tetsuya,Miyakawa, Takayuki,Ueda, Masafumi,Miyata, Okiko
supporting information; experimental part, p. 928 - 931 (2011/04/14)
A new aspect of enamine chemistry: The formation of N-alkoxyenamines from ketones has led to an efficient umpolung reaction. The alkylation of N-alkoxyenamines with trialkylaluminum compounds proceeded smoothly and gave α-alkylated ketones (see scheme). This reaction offers a simple transformation of ketones into α-substituted ketones without the need to isolate enamines and intermediary imines.
