76075-21-3

Basic information

• Product Name: ethyl 1-benzyl-1H-imidazole-5-carboxylic acid
• Synonyms: ethyl 1-benzyl-1H-imidazole-5-carboxylic acid
• CAS NO: 76075-21-3
• Molecular Weight: 230.266
• Mol File: 76075-21-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: ethyl 1-benzyl-1H-imidazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-benzyl-1H-imidazole-5-carboxylic acid(76075-21-3)
• EPA Substance Registry System: ethyl 1-benzyl-1H-imidazole-5-carboxylic acid(76075-21-3)

Safety Data

• Hazardous Substances Data: 76075-21-3(Hazardous Substances Data)

Upstream product

• 6436-90-4 ethyl 2-(benzylamino)acetate 
• 20353-93-9 [3-(dimethylamino)-2-azaprop-2-en-1-ylidene]-dimethylammonium chloride 
• 100-39-0 benzyl bromide 
• 23785-21-9 ethyl 1H-imidazole-4-carboxylate 
• 76075-07-5 N-benzyl-N-formyl-glycine ethyl ester 
• 333-20-0 potassium thioacyanate 
• 109-94-4 formic acid ethyl ester 
• 23785-21-9 1H-imidazole-5-carboxylic acid ethyl ester 
• 1399859-85-8 N-benzyl-N'-(2'-acetamido)thiourea 
• 100-44-7 benzyl chloride 
• 39123-65-4 3-benzyl-2-thioxotetrahydro-4H-imidazol-4-one 
• 287198-16-7 3-benzyl-2-(methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one 
• 1609282-78-1 1-benzyl-2-(methylthio)-5-imidazolcarbonitrile 
• 91025-37-5 ethyl 3-benzyl-2-sulfanylidene-2,3-dihydro-1H-imidazole-4-carboxylate 

Downstream Products

• 80304-50-3 1-benzyl-5-hydroxymethylimidazole 
• 85102-99-4 1-benzyl-1H-imidazole-5-carboxaldehyde 
• 82830-36-2 1-Benzyl-5-(chloromethyl)-1H-imidazolium chloride 
• 5317-07-7 1-Benzylimidazole-5-carboxylic Acid 

Relevant articles and documents

N-cyclopropyl methoxy imidazole amide derivative and application thereof in antitumor drugs

The invention belongs to the technical field of medicinal chemistry, and particularly relates to N-cyclopropyl methoxy imidazole amide derivatives, a preparation method and application of the N-cyclopropyl methoxy imidazole amide derivatives as an MEK inhibitor in antitumor drugs. The invention provides an N-cyclopropyl methoxy imidazole amide derivative as shown in a general formula, and geometric isomers or pharmaceutically acceptable salts, hydrates, solvates or prodrugs of the N-cyclopropyl methoxy imidazole amide derivative. The MEK inhibitor provided by the invention has specificity and effectiveness, and has a wider development prospect. Experimental results show that the N-cyclopropyl methoxy imidazole amide derivative synthesized by the research group has a prospect of developing targeted antitumor drugs.

Phenylethyl imidazole derivative and application thereof

The invention belongs to the technical field of medicines, and provides a novel phenylimidazole amide derivative shown as a general formula (I) (See the specification) and a geometrical isomer or pharmaceutically acceptable salt, hydrate, solvate and prodrug thereof, and preparation methods thereof. The compound can activate the activity of TGR5 and can be used for treating or preventing diseasesrelated to TGR5 activity regulation.

Preparation of 2'-13c-l-histidine starting from 13c-thiocyanate: Synthetic access to any site-directed stable isotope enriched l-histidine

1-Benzyl-2-(methylthio)-imidazole-5-ketone is obtained in a few simple steps starting from thiocyanate and glycine amide (glycin). Subsequent treatment with diethyl phosphorocyanidate and functional group manipulations gives 1-benzyl-5-chloromethylimidazolium chloride. This compound is converted under mild O'Donnell conditions into the corresponding L-histidine derivative. After deprotection L-histidine is obtained in good yield and 99% enantiomeric excess. 2'-13C-L-Histidine has been obtained via this new scheme with high (99%) 13C incorporation starting with commercially available 13C- thiocyanate. This synthetic scheme allows access to any isotopomer of L-histidine and many other biologically important imidazole derivatives.