7608-06-2

Basic information

• Product Name: HEPTYLZINC BROMIDE 0.5M SOLUTION IN
• Synonyms: HEPTYLZINC BROMIDE 0.5M SOLUTION IN;HEPTYLZINC BROMIDE, 0.5M SOLUTION IN TET;heptylzinc bromide solution;Heptylzinc bromide solution 0.5 in THF;1-Heptylzinc bromide 0.5 M in Tetrahydrofuran
• CAS NO: 7608-06-2
• Molecular Formula: C₇H₁₅BrZn
• Molecular Weight: 244.488
• Product Categories: Alkyl;Organozinc Halides;Reike and Organozinc Reagents
• Mol File: 7608-06-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 65 °C
• Flash Point: -17 °C
• Appearance: /
• Density: 0.965 g/mL at 25 °C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: HEPTYLZINC BROMIDE 0.5M SOLUTION IN(CAS DataBase Reference)
• NIST Chemistry Reference: HEPTYLZINC BROMIDE 0.5M SOLUTION IN(7608-06-2)
• EPA Substance Registry System: HEPTYLZINC BROMIDE 0.5M SOLUTION IN(7608-06-2)

Safety Data

• Hazard Codes: F,Xn
• Statements: 11-19-20/21/22-36/37/38-40-36/37
• Safety Statements: 16-26-33-36/37
• RIDADR: UN 2056 3/PG 2
• Hazardous Substances Data: 7608-06-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H15.BrH.Zn/c1-3-5-7-6-4-2;;/h1,3-7H2,2H3;1H;/q;;+1/p-1/rC7H15Zn.BrH/c1-2-3-4-5-6-7-8;/h2-7H2,1H3;1H/q+1;/p-1

Upstream product

• 629-04-9 1-Bromoheptane 
• 7440-66-6 zinc 

Downstream Products

• 629-59-4 tetradecane 
• 40775-32-4 1,4-diheptylbenzene 
• 629-62-9 pentadecane 
• 70659-87-9 N-benzyloctanoic amide 

Relevant articles and documents

Direct transformation of aryl 2-pyridyl esters to secondary benzylic alcohols by nickel relay catalysis

A direct transformation of aryl esters to secondary benzylic alcohols via tandem Ni-catalyzed cross-coupling reactions of aromatic 2-pyridyl esters with alkyl zinc reagents and carbonyl group reduction by Ni-H species is achieved. Preliminary mechanistic studies reveal that the Ni-H species is generated in situ via β-hydride elimination of the Negishi reagents. The reaction is catalyzed by bench-stable nickel salts under mild conditions with wide functional group tolerance.

α-1-C-Butyl-1,4-Dideoxy-1,4-Imino-L-Arabinitol as a second-Generation iminosugar-based oral α-Glucosidase inhibitor for improving postprandial hyperglycemia

We report on the synthesis and the biological evaluation of a series of α-1-C-alkylated 1,4-dideoxy-1,4-imino-l-arabinitol (LAB) derivatives. The asymmetric synthesis of the derivatives was achieved by asymmetric allylic alkylation, ring-closing metathesis, and Negishi cross-coupling as key reactions. α-1-C-Butyl-LAB is a potent inhibitor of intestinal maltase, isomaltase, and sucrase, with IC50 values of 0.13, 4.7, and 0.032 μM, respectively. Matrix-assisted laser desorption ionization time-of-flight mass spectrometric analysis revealed that this compound differs from miglitol in that it does not influence oligosaccharide processing and the maturation of glycoproteins. A molecular docking study of maltase-glucoamylase suggested that the interaction modes and the orientations of α-1-C-butyl-LAB and miglitol are clearly different. Furthermore, α-1-C-butyl-LAB strongly suppressed postprandial hyperglycemia at an early phase, similar to miglitol in vivo. It is noteworthy that the effective dose was about 10-fold lower than that for miglitol. α-1-C-Butyl-LAB therefore represents a new class of promising compounds that can improve postprandial hyperglycemia.