761338-34-5Relevant articles and documents
The synthesis of a Series of (α-Amino)indol-3-yl Ketones
Sanchez, Joseph P.,Parcell, Robert F.
, p. 469 - 474 (2007/10/02)
A series of -2-methyl-1-propanones and cyclopentylmethanones has been synthesized by a variety of reductive reactions performed on the corresponding series of (α-azido)indol-3-yl ketones.One of the more interesting reductive procedures involved the palladium-catalyzed decomposition of formic acid with the formation of hydrogen in situ.The (α-azido)ketones were prepared in excellent yield by the displacement of the tertiary bromine atom from the (α-bromo)ketones using sodium azide in N,N-dimethylformamide.Bromination was accomplished by using either cupric bromide in ethyl acetate/chloroform or phenyltrimethylammonium tribromide in tetrahydrofuran.