761426-58-8

Basic information

• Product Name: 1H-Imidazole, 4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-(4-fluorophenyl)-
• CAS NO: 761426-58-8
• Molecular Formula: C16H23FN2OSi
• Molecular Weight: 306.455
• Mol File: 761426-58-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole, 4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole, 4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-(4-fluorophenyl)-(761426-58-8)
• EPA Substance Registry System: 1H-Imidazole, 4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-(4-fluorophenyl)-(761426-58-8)

Safety Data

• Hazardous Substances Data: 761426-58-8(Hazardous Substances Data)

Upstream product

• 761426-57-7 [1-(4-fluoro-phenyl)-1H-imidazol-4-yl]-methanol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 288-32-4 1H-imidazole 
• 1000-50-6 butyldimethylsilyl chloride 

Downstream Products

• 761426-59-9 4-(tert-butyl-dimethyl-silanyloxymethyl)-1-(4-fluoro-phenyl)-2-methyl-1H-imidazole 

Relevant articles and documents

Imidazole derivatives

The present invention relates to imidazole derivatives of formula I wherein R1, R2, R3 and R4 are described hereinabove. These compounds can be used in the treatment or prevention of mGluR5 receptor mediated disorders. These compounds are useful, inter alia, in the treatment of genitourinary diseases.

IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES

4-[1-Aryl-imidazol-4-ylethynyl]-2-alkyl-pyridine and 1-heteroaryl-imidazol-4-ylethynyl]-2-alkyl-pyridine derivatives and pharmaceutically acceptable salts thereof for the treatment or prevention of disorders mediated full or in part by metabotropic glutamate receptor 5, e.g. acute, traumatic and chronic degenerative processes of the nervous system, such as Alzheimer's disease, senile dementia, Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis and multiple sclerosis, psychiatric diseases such as schizophrenia and anxiety, depression, pain and drug dependency.