761434-36-0 Usage
Description
(9S)-9-(9-Phenanthrenyloxy)-Cinchonan-6'-ol is a chemical compound characterized by its unique molecular structure, which features a cinchonan-6'-ol core with a phenanthrenyloxy group attached at the 9th position. (9S)-9-(9-Phenanthrenyloxy)-Cinchonan-6'-ol is derived from cinchona alkaloids, a class of natural products that have been extensively utilized as chiral catalysts in asymmetric synthesis. The incorporation of the phenanthrenyloxy group on the 9th position endows the compound with distinct properties, making it a promising candidate for applications in organic synthesis and medicinal chemistry.
Uses
Used in Organic Synthesis:
(9S)-9-(9-Phenanthrenyloxy)-Cinchonan-6'-ol is used as a chiral catalyst in organic synthesis for its ability to facilitate asymmetric reactions. (9S)-9-(9-Phenanthrenyloxy)-Cinchonan-6'-ol's unique structure allows for the selective formation of desired enantiomers, which is crucial in the production of pharmaceuticals and other chiral molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (9S)-9-(9-Phenanthrenyloxy)-Cinchonan-6'-ol is used as a key intermediate or building block for the development of novel therapeutic agents. (9S)-9-(9-Phenanthrenyloxy)-Cinchonan-6'-ol's structural diversity and potential for further modification make it a valuable tool for designing and synthesizing new drugs with improved pharmacological properties.
Used in Research and Development:
(9S)-9-(9-Phenanthrenyloxy)-Cinchonan-6'-ol is also utilized in research and development as a model compound for studying the effects of structural modifications on the properties and reactivity of cinchona alkaloid derivatives. This knowledge can be applied to the design of more efficient catalysts and the development of innovative synthetic methods in organic chemistry.
Used in Pharmaceutical Industry:
Within the pharmaceutical industry, (9S)-9-(9-Phenanthrenyloxy)-Cinchonan-6'-ol is used as a chiral catalyst for the synthesis of enantiomerically pure drugs. (9S)-9-(9-Phenanthrenyloxy)-Cinchonan-6'-ol's ability to selectively promote asymmetric reactions is essential for the production of drugs with desired biological activities and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 761434-36-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,6,1,4,3 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 761434-36:
(8*7)+(7*6)+(6*1)+(5*4)+(4*3)+(3*4)+(2*3)+(1*6)=160
160 % 10 = 0
So 761434-36-0 is a valid CAS Registry Number.
761434-36-0Relevant articles and documents
ASYMMETRIC MICHAEL AND ALDOL ADDITION USING BIFUNCTIONAL CINCHONA-ALKALOID-BASED CATALYSTS
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Page/Page column 87, (2008/06/13)
One aspect of the present invention relates to quinine-based and quinidine-based catalysts. Another aspect of the invention relates to a method of preparing a derivatized quinine-based or quinidine-based catalyst comprising 1) reacting quinine or quinidine with 5 base and a compound that has a suitable leaving group, and 2) converting the ring methoxy group to a hydroxy group. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene or azo compound or prochiral aldehyde or prochiral ketone, comprising the step of: reacting a prochiral electron-deficient alkene or azo compound or prochiral aldehyde or prochiral 10 ketone with a nucleophile in the presence of a catalyst; thereby producing a chiral, non racemic compound; wherein said catalyst is a derivatized quinine or quinidine. Another aspect of the present invention relates to a method of kinetic resolution, comprising the step of reacting racemic chiral alkene with a nucleophile in the presence of a derivatized quinine or quinidine.
