76155-50-5Relevant articles and documents
Comparing the use of 2-methylenenapthyl, 4-methoxybenzyl, 3,4-dimethoxybenzyl and 2,4,6-trimethoxybenzyl as N-H protecting groups for p-tolyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-1-thio-β-d-glucosides
Sarkar, Sourav,Sucheck, Steven J.
, p. 393 - 400 (2011/04/15)
A hurdle in glycosylation reactions of 2-acetamido glycosyl donors is the formation of a stable and unreactive oxazoline that decreases the yield of these reactions significantly. As an effort to prevent oxazoline formation during glycosylation reactions,
Discovery of the chemical function of glycosidases: Design, synthesis, and evaluation of mass-differentiated carbohydrate libraries
Yu, Yang,Ko, Kwang-Seuk,Zea, Corbin J.,Pohl, Nicola L.
, p. 2031 - 2033 (2007/10/03)
Equation presented. Discovery of the catalytic chemical function of the many putative glycosidases coded in genomes currently relies on individual testing of possible substrates, usually as their p-nitrophenol conjugate. Herein, we present an alternative chemical proteomics approach using a synthetic mass-differentiated heat-stable substrate library with mass spectrometry readout. Library components do not serve as reaction inhibitors and both primary and secondary enzyme substrates can be delineated.