76217-07-7

Basic information

• Product Name: 2-Butanone, 4-(4-methoxyphenyl)-4-phenyl-
• CAS NO: 76217-07-7
• Molecular Formula: C17H18O2
• Molecular Weight: 254.329
• Mol File: 76217-07-7.mol
• Article Data: 44

Chemical Properties

• CAS DataBase Reference: 2-Butanone, 4-(4-methoxyphenyl)-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanone, 4-(4-methoxyphenyl)-4-phenyl-(76217-07-7)
• EPA Substance Registry System: 2-Butanone, 4-(4-methoxyphenyl)-4-phenyl-(76217-07-7)

Safety Data

• Hazardous Substances Data: 76217-07-7(Hazardous Substances Data)

Upstream product

• 696-62-8 para-iodoanisole 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 3009-79-8 p-anisylmercuric chloride 
• 100-66-3 methoxybenzene 
• 1896-62-4 (E)-benzalacetone 
• 5720-07-0 4-methoxyphenylboronic acid 
• 1709-60-0 4-methoxybenzenesulfinic acid 
• 254454-47-2 4-methoxyphenylzinc iodide 
• 3815-30-3 4-(4-methoxyphenyl)-3-buten-2-one 
• 98-80-6 phenylboronic acid 
• 100-52-7 benzaldehyde 
• 917-64-6 methyl magnesium iodide 
• 541-50-4 2-acetoacetic acid 
• 720-44-5 1-(4-methoxyphenyl)-1-phenylmethanol 

Relevant articles and documents

Enantioselective Conjugate Addition of Stabilized Arylzinc Iodide to Enones: an Improved Protocol of the Hayashi Reaction

Stabilised arylzinc iodide, prepared by direct insertion of zinc into aryl iodides, were used as nucleophiles in the Hayashi Rh-catalysed enantioselective conjugate addition to enones. The reaction conditions were optimized in the addition of phenylzinc i

Ligand-free palladium-catalyzed tandem pathways for the synthesis of 4,4-diarylbutanones and 4,4-diaryl-3-butenones under microwave conditions

Two efficient Pd-catalyzed tandem pathways for the synthesis of 4,4-diaryl-2-butanones and 4,4-diaryl-3-buten-2-ones were elaborated. The first step in both procedures was the Heck coupling of methyl vinyl ketone (MVK) and various aryl iodides leading to 4-aryl-3-buten-2-one with the yield of up to 92% in 1?hr. The second step performed with the same catalyst and a new portion of aryl iodide in the presence K2CO3 as a base produced 4,4-diaryl-3-buten-2-ones in high yield. Reaction selectivity changed completely to saturated 4,4-diaryl-2-butanones, reductive Heck products, when a tertiary amine was used instead of K2CO3. Due to the application of microwave irradiation (MW), the desired products were obtained in high yield in a short time (4?hr), using 0.5?mol% of the Pd (OAc)2 catalyst without additional ligands.

Aqueous Asymmetric 1,4-Addition of Arylboronic Acids to Enones Catalyzed by an Amphiphilic Resin-Supported Chiral Diene Rhodium Complex under Batch and Continuous-Flow Conditions

A rhodium-chiral diene complex immobilized on amphiphilic polystyrene-poly(ethylene glycol) (PS-PEG) resin (PS-PEG-diene?-Rh) has been developed. The immobilized rhodium-chiral diene complex (PS-PEG-diene?-Rh) efficiently catalyzed the asymmetric 1,4-addition of various arylboronic acids to cyclic or linear enones in water under batch conditions to give the corresponding β-arylated carbonyl compounds in excellent yields and with excellent enantioselectivity. The catalyst was readily recovered by simple filtration and reused 10 times without loss of its catalytic activity and enantioselectivity. Moreover, a continuous-flow asymmetric 1,4-addition in a flow reactor containing PS-PEG-diene?-Rh proceeded efficiently at 50 °C with retention of high enantioselectivity. Long-term continuous-flow asymmetric 1,4-addition during 12 h readily gave the desired product on a 10 g scale with high enantioselectivity.