76227-93-5

Basic information

• Product Name: ethyl 3-((4-chlorophenyl)amino)propanoate
• Synonyms: ethyl 3-((4-chlorophenyl)amino)propanoate
• CAS NO: 76227-93-5
• Molecular Weight: 227.691
• Mol File: 76227-93-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: ethyl 3-((4-chlorophenyl)amino)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-((4-chlorophenyl)amino)propanoate(76227-93-5)
• EPA Substance Registry System: ethyl 3-((4-chlorophenyl)amino)propanoate(76227-93-5)

Safety Data

• Hazardous Substances Data: 76227-93-5(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 140-88-5 ethyl acrylate 

Downstream Products

• 197513-34-1 N-(4-chloro-phenyl)-N-(toluene-4-sulfonyl)-β-alanine 
• 23432-43-1 6-chloro-4-hydroxyquinoline 
• 21617-19-6 3-(4-chlorophenylamino)propionic acid 

Relevant articles and documents

Synthesis of 2,3-Dihydro-4-pyridones and 4-Pyridones by the Cyclization Reaction of Ester-Tethered Enaminones

2,3-Dihydro-4-pyridone skeleton is an important building block in organic synthesis because it features several reaction sites with nucleophilic or electrophilic properties. Herein, we disclose a method for its formation by intramolecular cyclization of ester-tethered enaminones, which can easily be synthesized from readily available materials, such as amines, activated alkynes, and activated alkenes. 2,3-Dihydro-4-pyridones have been isolated in 41-90% yields. We also demonstrate the transformation of these heterocycles into another important class of compounds, 4-pyridones, by utilizing 2,3,5,6-tetrachloro-p-benzoquinone (chloranil) as an oxidizing agent. The latter products were isolated in 65-94% yields.

(Substituted phenylamino)propionic acid ethyl ester compounds and preparation method thereof

The invention discloses (substituted phenylamino)propionic acid ethyl ester compounds and a preparation method thereof. The method comprises the following steps: a substituted aniline compound and ethyl acrylate are used as raw materials, a catalytic reac

A green and convenient approach for the one-pot solvent-free synthesis of coumarins and β-amino carbonyl compounds using Lewis acid grafted sulfonated carbon@titania composite

Abstract: This paper reports an efficient protocol for the synthesis of coumarins via Pechmann reaction, and β-amino carbonyl compounds via aza-Michael reaction using catalytic amount of solid Lewis acid catalyst, C@TiO2–SO3–SbCl2. Six different catalysts were prepared by covalent immobilization of homogeneous Lewis acids onto sulfonated carbon@titania composite derived from amorphous carbon and nano-titania. Among various catalysts tested, C@TiO2–SO3–SbCl2 showed superior catalytic activity. The catalyst could be recycled without significant loss of its catalytic activity and demonstrated versatile catalysis for a wide range of substrates. Graphical abstract: [Figure not available: see fulltext.]