762274-65-7

Basic information

• Product Name: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-alanyl-3-methyl-L-valyl-, phenylmethyl ester
• CAS NO: 762274-65-7
• Molecular Formula: C27H41N3O6
• Molecular Weight: 503.639
• Mol File: 762274-65-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-alanyl-3-methyl-L-valyl-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-alanyl-3-methyl-L-valyl-, phenylmethyl ester(762274-65-7)
• EPA Substance Registry System: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-alanyl-3-methyl-L-valyl-, phenylmethyl ester(762274-65-7)

Safety Data

• Hazardous Substances Data: 762274-65-7(Hazardous Substances Data)

Upstream product

• 16948-16-6 N-(tert-butoxycarbonyl)-N-methyl-L-alanine 
• 13734-31-1 (S)-N-tert-butoxycarbonyl-N-methyl-2-amino-propionic acid 
• 62965-35-9 N-tert-butyloxycarbonyl-L-tert-leucine 
• 37787-77-2 Boc-L-proline benzyl ester 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1363150-47-3 tert-butyl(S)-1-((S)-1-((S)-2-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)pyrrolidin-1-yl-3,3-dimethyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl)methylcarbamate 
• 1363150-35-9 (S)-N-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-yl)-1-((S)3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)pyrrolidine-2-carboxamide hydrochloride 

Relevant articles and documents

Design, synthesis and biological evaluation of new bivalent quinazoline analogues as IAP antagonists

We recently reported the biological evaluations of monovalent IAP antagonist 7 with good potency (MDA-MB-231, IC50 = 19 nM). In an effort to increase cellular activity and improve favorable drug-like properties, we newly designed and synthesized bivalent analogues based on quinazoline structure of 7. Optimization of cellular potency and CYP inhibition led to the identification of 27, which showed dramatic increase of over 100-fold (IC50 = 0.14 nM) and caused substantial tumor regressions in MDA-MB-231 xenograft model. These results strongly support 27 as a promising bivalent antagonist for the development of an effective anti-tumor approaches.

TETRAPEPTIDE ANALOGS

Compounds, compositions and methods for treatment of hyperproliferative diseases, such as cancer are provided.