7623-10-1

Basic information

• Product Name: Propanoyl chloride, 3-chloro-2-methyl-
• Synonyms: 2-methyl-3-chloropropionyl chloride;Propanoyl chloride, 3-chloro-2-methyl-;3-chloro-2-methylpropionyl chloride;3-chloro-2-methyl-propanoyl chloride;Propanoyl chloride,3-chloro-2-methyl
• CAS NO: 7623-10-1
• Molecular Formula: C4H6Cl2O
• Molecular Weight: 140.997
• Mol File: 7623-10-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: -90°C
• Boiling Point: 189.51°C (rough estimate)
• Density: 1.0174
• Refractive Index: 1.4079 (estimate)
• CAS DataBase Reference: Propanoyl chloride, 3-chloro-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoyl chloride, 3-chloro-2-methyl-(7623-10-1)
• EPA Substance Registry System: Propanoyl chloride, 3-chloro-2-methyl-(7623-10-1)

Safety Data

• Hazardous Substances Data: 7623-10-1(Hazardous Substances Data)

Upstream product

• 79-30-1 isobutyryl chloride 
• 16674-04-7 (R)-(+)-β-chloro-isobutyric acid 
• 7782-50-5 chlorine 
• 56-23-5 tetrachloromethane 
• 7791-25-5 sulfuryl dichloride 
• 94-36-0 dibenzoyl peroxide 
• 1910-47-0 3-hydroxyisobutyric acid 

Downstream Products

• 920-46-7 Methacryloyl chloride 
• 202667-45-6 2-methyl-5,6-dihydrocyclopenta[f]-1H-indene 
• 58472-46-1 4'-fluoro-2-methyl-3-chloro-propiophenone 
• 1189544-22-6 p-chlorophenyl β-chloroisobutyrate 
• 90631-30-4 (+/-)-5-(3-chloro-2-methylpropionamido)-4-cyano-1-(4-ethyl-2,3,5,6-tetrafluorophenyl)pyrazole 
• 37795-71-4 3-methyl-2,3-dihydro-isoxazolo[3,2-b]quinazolin-9-one 
• 81785-21-9 β-chloro-isobutyric acid anilide 

Relevant articles and documents

Cu(I)-catalyzed oxidative cyclization of alkynyl oxiranes and oxetanes

In the presence of a Cu(I) catalyst and a pyridine oxide, alkynyl oxiranes and oxetanes can be converted into functionalized five- or six-membered α,β-unsaturated lactones or dihydrofuranaldehydes. This new oxidative cyclization is proposed to proceed via an unusual allenyloxypyridinium intermediate.

An improved synthesis of captopril

An improved synthesis of captopril using methacrylic acid as the starting material is described. Treatment of methacrylic acid (I) with a hydrogen halide gave the 3-halogeno-2-methylpropanoic acids II and III, which were treated with thionyl chloride to yield the corresponding 3-halogeno-2-methylpropanoyl chlorides IV and V. Treatment of IV or V with L-proline yielded the N-(R,S-3-halogeno-2-methylpropanoyl)-L-prolines VI and VII, which were separated into optically pure R- and S-diastereoisomers using dicyclohexylamine. Treatment of halides of VI or VII with methanolic ammonium hydrosulfide gave captopril in 28% yield.