76251-01-9

Basic information

• Product Name: methyl 2-(3,5-dibromo-2-hydroxyphenyl)acetate
• Synonyms: methyl 2-(3,5-dibromo-2-hydroxyphenyl)acetate
• CAS NO: 76251-01-9
• Molecular Weight: 323.969
• Mol File: 76251-01-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl 2-(3,5-dibromo-2-hydroxyphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(3,5-dibromo-2-hydroxyphenyl)acetate(76251-01-9)
• EPA Substance Registry System: methyl 2-(3,5-dibromo-2-hydroxyphenyl)acetate(76251-01-9)

Safety Data

• Hazardous Substances Data: 76251-01-9(Hazardous Substances Data)

Upstream product

• 21891-69-0 2-(3,5-dibromo-2-hydroxyphenyl)acetic acid 
• 67-56-1 methanol 
• 4186-54-3 2-(bromomethyl)-4,6-dibromophenol 
• 76250-93-6 1-<(carbomethoxy)methyl>benzene oxide 
• 22446-37-3 methyl (2-hydroxyphenyl)acetate 

Relevant articles and documents

SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF DIABETES

The present invention concerns the use of compounds for preventing and/or treating diabetes, for modulating glucose, insulin, and/or triglyceride levels; for reducing blood glucose level; for maintaining or increasing insulin level; for increasing insulin secretion; increasing insulin sensitivity; or decreasing insulin resistance in a subject. These novel uses have been found for compounds represented by Formula I and pharmaceutically acceptable salts. wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F or OH; R2 is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH or CH2Ph; R4 is H, F or OH; Q is 1) (CH2)mC(O)OH wherein m is 1 or 2, 2) CH(CH3)C(O)OH, 3) C(CH3)2 C(O)OH, 4) CH(F)- C(O)OH, 5) CF2- C(O)OH, or 6) C(O)- C(O)OH.

SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TISSUE SELF-REPAIR AND REGENERATION

Described herein are compounds of Formula I, or pharmaceutically acceptable salts thereof, or combinations thereof, as well as uses thereof. Such uses include promoting tissue self-repair or tissue regeneration of an organ, stimulating the generation of tissue growth, modulating (e.g. increasing) the level of a tissue-repair marker, treating physical injury in an organ, tissue, or cell, promoting wound healing as well as anti-aging applications. Corresponding compositions, methods and uses are also described. Formula I wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F of OH; R2 is H, F, OH, C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH, or CH2Ph; R4 is H, F or OH; Q is 1) (CH2),C(0)OH wherein m is 1 or 2 2) CH(CH3)C(0)OH, 3) C(CH3)2C(0)OH, 4) CH(F)-C(0)OH, 5) CF2-C(0)OH or 6) C(0)-C(0)OH.

Aromatization of arene 1,2-oxides. 1,2-Oxides of methyl phenylacetate and methyl trans-cinnamate

Substituent migration is observed only to a minor extent during aromatization of the 1,2-oxide of methyl phenylacetate to methyl (o-hydroxyphenyl)acetate; the major aromatization pathway does not involve substituent migration. Substituent migration is not observed during aromatization of the 1,2-oxide of methyl trans-cinnamate to methyl o-coumarate.