76263-92-8

Basic information

• Product Name: 1-Piperidinecarbonyl chloride, 3-hydroxy- (9CI)
• Synonyms: 1-Piperidinecarbonyl chloride, 3-hydroxy- (9CI)
• CAS NO: 76263-92-8
• Molecular Formula: C6H10ClNO2
• Molecular Weight: 163.6021
• Product Categories: ACIDHALIDE
• Mol File: 76263-92-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 307.9±31.0 °C(Predicted)
• Appearance: /
• Density: 1.356±0.06 g/cm3(Predicted)
• PKA: 14.42±0.20(Predicted)
• CAS DataBase Reference: 1-Piperidinecarbonyl chloride, 3-hydroxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarbonyl chloride, 3-hydroxy- (9CI)(76263-92-8)
• EPA Substance Registry System: 1-Piperidinecarbonyl chloride, 3-hydroxy- (9CI)(76263-92-8)

Safety Data

• Hazardous Substances Data: 76263-92-8(Hazardous Substances Data)

Usage

Derived from

piperidine

Functional groups

carbonyl chloride group, hydroxy group

Attachment position

third carbon of the piperidine ring

Use

versatile intermediate in organic synthesis

Applications

production of pharmaceuticals and agrochemicals

Capable of

undergoing various chemical reactions to yield different derivatives with a range of biological activities

Value

valuable in medicinal chemistry and drug development.

Upstream product

• 6859-99-0 3-hydroxypiperazine 
• 75-44-5 phosgene 
• 75431-17-3 3<(Chloroformyl)oxy>piperidinium p-toluenesulfonate 

Relevant articles and documents

Anti-Bredt Molecules. 3. 3-Oxa-1-azabicyclononan-2-one and 6-Oxa-1-azabicyclooctan-7-one, Two Atom-Bridged Bicyclic Urethanes Possessing Bridgehead Nitrogen

The first atom-bridged bicyclic urethanes possessing bridgehead nitrogen have been synthesized and their properties examined briefly. 3-Oxa-1-azabicyclononan-2-one was synthesized from 3-(hydroxymethyl)-piperidine and phosgene by using two alternate reaction schemes. 6-Oxa-1-azabicyclooctan-7-one was synthesized similarly from 3-hydroxypiperidine.Both compounds were stable, white, crystalline solids with normal infrared spectra.They were rather stable to acids and bases, but phosphoric acid initiated ring-opening polymerization demonstrated strain in the system.A novel O -> N rearrangement of two aminochloroformates to hydroxy N-carbamoyl chlorides was demonstrated.