7627-38-5

Basic information

• Product Name: 2,4-Dichloro-5-(chloromethyl)pyrimidine
• Synonyms: 2,4-Dichloro-5-(chloromethyl)pyrimidine;PyriMidine, 2,4-dichloro-5-(chloroMethyl)-
• CAS NO: 7627-38-5
• Molecular Formula: C₅H₃Cl₃N₂
• Molecular Weight: 197.452
• Mol File: 7627-38-5.mol
• Article Data: 26

Chemical Properties

• Melting Point: 63-64°
• Boiling Point: 90-100 °C(Press: 0.001 Torr)
• Appearance: White to cream/Solid
• Density: 1.548±0.06 g/cm3(Predicted)
• PKA: -3.42±0.29(Predicted)
• CAS DataBase Reference: 2,4-Dichloro-5-(chloromethyl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-5-(chloromethyl)pyrimidine(7627-38-5)
• EPA Substance Registry System: 2,4-Dichloro-5-(chloromethyl)pyrimidine(7627-38-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 7627-38-5(Hazardous Substances Data)

Usage

Uses

2,4-Dichloro-5-(chloromethyl)pyrimidine is an intermediate; used in preparation of fused pyrimidine compounds for the treatment of cancers associated with EGFR and HER2 mutations.

Upstream product

• 4433-40-3 5-hydroxymethyl uracil 
• 4433-40-3 5-(hydroxymethyl)pyrimidine-2,4-diol 
• 3590-48-5 5-(chloromethyl)pyrimidine-2,4-diol 

Downstream Products

• 774232-76-7 (2,4-dichloro-pyrimidin-5-yl-methyl)-(2-fluoro-4-methoxy-phenyl)amine 
• 7627-44-3 2, 4-dichloro-5-(iodomethyl)pyrimidine 
• 501000-26-6 2-chloro-5-(chloromethyl)-N-(2,2-dimethylpropyl)-4-pyrimidineamine 
• 1289388-21-1 C₈H₉Cl₂N₃ 

Relevant articles and documents

PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Disclosed are a compound selected from novel pyrimido[4,5-d]pyrimidin-2-one derivative compounds having excellent anti-proliferative activity against cancer cells, pharmaceutically acceptable salts thereof, hydrates thereof and stereoisomers thereof, a method for preparing the compound, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative diseases containing the compound as an active ingredient, and an anticancer composition against cancer cells, containing the compound as an active ingredient. The compounds of this invention exhibit most excellent selective inhibitory activity agaist LCK and anti-proliferative activity against cancer cells, thus being useful for inhibiting cancer cells, and for preventing or treating cancer metastasis and proliferative diseases.

NOVEL PYRIMIDO[4,5-d]PYRIMIDIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS

The present invention is a pyrimido [4, 5-d] pyrimid -2 -one derivative compound showing an excellent anti-proliferative effect on cancer cells. The present invention relates to a pharmaceutically acceptable salt, a hydrate thereof, a stereoisomer thereof, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative diseases containing the same as an active ingredient, and an anticancer composition comprising the same as an active ingredient.

BICYCLIC NITROGEN CONTAINING HETEROCYCLES AS INHIBITORS OF SALT-INUCED KINASE SIK2

Provided are compounds of the Formula (I), and salts and solvates thereof: (Formula (I)) wherein R2, R3, X1, L, A, R6, R7 and Z are defined in the specification. The compounds are inhibitors of salt-inducible kinase (SIK), particular SIK2, and are useful in therapy, particularly in the treatment of a proliferative disorder, a benign neoplasm, pathological angiogenesis, an inflammatory disease or condition, a musculoskeletal disease or condition, an autoimmune disease, a haematological disease or condition, a neurological disease or condition, a psychiatric disorder, or a metabolic disorder.