76335-36-9Relevant articles and documents
Diastereoselective three-component Mannich reaction catalyzed by silica-supported ferric hydrogensulfate
Eshghi, Hossein,Rahimizadeh, Mohammad,Hosseini, Mohsen,Javadian-Saraf, Aida
, p. 197 - 203 (2013/07/27)
A highly anti-diastereoselective three-component Mannich reaction of aromatic amines and aromatic aldehydes with cyclohexanone in the presence of silica-supported ferric hydrogensulfate has been developed. The best selectivity was obtained where there were electron-donating groups on both aldehyde and amine. Selectivity decreases when electron-withdrawing groups are present on the aldehyde; in these cases selectivity is improved if an electron-donating group is present on the amine.